1,2,3-Propanetriol, diacetate (CAS 25395-31-7) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Sweet

1,2,3-Propanetriol, diacetate

CAS 25395-31-7

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 1,2,3-Propanetriol, diacetate?

1,2,3-Propanetriol, diacetate is a synthetic compound primarily used as a solvent and fixative in perfumery. It’s found in some cosmetic formulations and personal care products where it helps stabilize fragrance blends. This ingredient matters because it extends the longevity of scents without contributing its own strong odor, making it a valuable tool for perfumers working with delicate compositions.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Low toxicity profile
⚠ Avoid undiluted contact with skin
CAS
25395-31-7
Formula
Mixture
MW
Variable
Odor Family
Woody · Sweet
Layer 1 · Enthusiast

What Does 1,2,3-Propanetriol, diacetate Smell Like?

1,2,3-Propanetriol, diacetate has a very mild, nearly neutral odor profile with faint waxy undertones. Its primary function isn’t olfactory impact but rather as a workhorse ingredient that subtly rounds out sharp edges in fragrance compositions. In blends, it behaves like an invisible hand – smoothing transitions between notes without announcing its presence. The dry-down shows exceptional stability, maintaining the integrity of more volatile components over time.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

1,2,3-Propanetriol, diacetate is a diester formed by the acetylation of glycerol. This synthetic compound belongs to the class of polyol esters, known for their solvent properties and low volatility. Industrial synthesis typically involves direct esterification of glycerol with acetic acid under controlled conditions. The molecule’s symmetrical structure contributes to its stability and compatibility with a wide range of fragrance ingredients.

Physical & Chemical Properties

AppearanceColorless liquid
SolubilityMiscible with most organic solvents

Perfumer Guide

Note Position
Base
Volatility
Very low
Blending
Excellent
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Fixative/solvent
Cosmetics0.5-2%Up to 3%Stabilizer

Classic Accords

Tip: Use as a neutral base for delicate floral compositions requiring extended longevity.

Alternatives & Comparisons

1
Triacetin CAS 102-76-1

Glycerol triacetate offers similar solvent properties with slightly higher viscosity.

2
Dipropylene glycol CAS 25265-71-8

Alternative solvent with better water solubility for aqueous formulations.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

No specific RIFM assessment found for this compound.

Sustainability

As a synthetic compound, 1,2,3-Propanetriol, diacetate is produced through controlled chemical processes with minimal environmental impact. Its production doesn’t rely on natural resources, making it a sustainable choice when compared to some plant-derived fixatives. The manufacturing process can be optimized for energy efficiency and waste reduction.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 25395-31-7

    Odor & Flavor

    “ethereal odor.”📖 Arctander
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

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