2,2,5-Trimethyl-5-pentylcyclopentanone (CAS 65443-14-3) — Woody Base Note Fragrance Ingredient
2,2,5-Trimethyl-5-pentylcyclopentanone
CAS 65443-14-3
What Is 2,2,5-Trimethyl-5-pentylcyclopentanone?
2,2,5-Trimethyl-5-pentylcyclopentanone is a synthetic fragrance ingredient used to add warm, woody, and slightly musky notes to perfumes. It’s found in upscale personal care products and fine fragrances. This compound is valued for its ability to enhance depth and longevity in fragrance compositions, making it a subtle but impactful player in modern perfumery.
Safety Profile
GENERALLY SAFEWhat Does 2,2,5-Trimethyl-5-pentylcyclopentanone Smell Like?
2,2,5-Trimethyl-5-pentylcyclopentanone offers a warm, woody, and slightly musky aroma with a subtle animalic undertone. It evolves from a fresh, slightly green top note to a rich, woody heart, finally settling into a soft, musky base. The scent is reminiscent of sun-warmed cedarwood with a hint of amber, making it versatile for both masculine and feminine fragrances.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the woody and musky facets, adding depth and longevity to the fragrance.
Contributes to the warm, woody base, complementing the citrus and incense notes.
2D Molecular Structure
SMILES: CCCCCC1(C)CCC(C)(C)C1=O
Chemistry, Properties & Perfumer Guide
The Chemistry
2,2,5-Trimethyl-5-pentylcyclopentanone is a synthetic ketone with a cyclopentanone core. It is typically synthesized through alkylation and cyclization reactions. The pentyl side chain contributes to its woody and musky characteristics, while the methyl groups enhance its volatility and diffusion.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Adds warmth and depth |
| Personal Care | 0.5-2% | Up to 5% | Used for woody-musky notes |
Classic Accords
Tip: Use in small amounts to avoid overpowering other notes.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No current IFRA restrictions.
RIFM Assessment
Currently under review by RIFM for comprehensive safety assessment.
Sustainability
As a synthetic ingredient, 2,2,5-Trimethyl-5-pentylcyclopentanone is produced in controlled environments with minimal environmental impact. Its synthesis avoids the ethical and ecological concerns associated with natural musk sourcing.
Explore 2,2,5-Trimethyl-5-pentylcyclopentanone
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 65443-14-3Physical Properties
| Molecular Weight | 196.33 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 4.2🔬 PubChem |
| Boiling Point | 233 °C🔬 EPA CompTox |
| Vapor Pressure | 0.069 mmHg @ 25°C📊 OPERA |
| Flash Point | 90 °C🔬 EPA CompTox |
| Involatility Index | 0.0053💻 Calculated |
| log Kp (skin permeability) | -0.916💻 Calculated |
| SMILES | CCCCCC1(CCC(C1=O)(C)C)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Heart💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 2.5 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | muskywoody• leffingwell |
| Functional Groups | ketone💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID9052341
Physical Properties
| Molecular Weight | 196.334 g/mol🔬 EPA CompTox |
| Density | 0.867 g/cm^3🔬 EPA CTX |
| Boiling Point | 233 °C🔬 EPA CTX |
| Melting Point | 9.96 °C📊 OPERA |
| Flash Point | 90.5 °C🔬 EPA CTX |
| Refractive Index | 1.44 Dimensionless📊 OPERA |
| Molar Volume | 229.142 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.7 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 4.455 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.455 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.1 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.069 mmHg🔬 EPA CTX |
| Viscosity | 3.05 cP📊 OPERA |
| Surface Tension | 28.046 dyn/cm📊 OPERA |
| Thermal Conductivity | 123.448 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 4 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 60.349 cm^3/mol📊 OPERA |
| Polarizability | 23.924 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
Related Research
- Isoborneol (CAS 124-76-5) — Woody Top Note Fragrance Ingredient
- Grapefruit oil terpenes (CAS 68917-32-8) — Citrus Top Note Fragrance Ingredient
- Methyl N-methylanthranilate (CAS 85-91-6) — Floral Middle Note Fragrance Ingredient
- 5,9-Undecadien-2-ol,6,10-dimethyl-,acetate (CAS 91482-37-0) — Green Top to middle Note Fragrance Ingredient
![9,10-Anthracenedione, 1,4-bis[(4-methylphenyl)amino]- (CAS 128-80-3) — Citrus N/A Note Fragrance Ingredient](https://thegoodscents.company/wp-content/uploads/2026/04/9-10-anthracenedione-1-4-bis-1-5-768x439.webp)
