2-Methyl-4-(camphenyl-8)-cyclohexanone (CAS 68901-22-4) — Woody Middle to base Note Fragrance Ingredient
2-Methyl-4-(camphenyl-8)-cyclohexanone
CAS 68901-22-4
What Is 2-Methyl-4-(camphenyl-8)-cyclohexanone?
2-Methyl-4-(camphenyl-8)-cyclohexanone is a synthetic fragrance ingredient used in perfumery for its unique woody and camphoraceous notes. You might encounter it in high-end colognes and woody perfumes where it adds depth and complexity. This ingredient matters because it helps create sophisticated, long-lasting fragrance profiles that evolve beautifully on the skin.
Safety Profile
GENERALLY SAFEWhat Does 2-Methyl-4-(camphenyl-8)-cyclohexanone Smell Like?
2-Methyl-4-(camphenyl-8)-cyclohexanone opens with a crisp, camphoraceous blast reminiscent of freshly cracked peppermint and eucalyptus, but quickly settles into a refined woody heart. The dry-down reveals a sophisticated cedar-like character with subtle hints of dry tobacco leaves. Its evolution is remarkable – starting bright and medicinal, then warming to a comforting, masculine woodiness that lingers close to the skin for hours.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a woody-modifier to enhance the sandalwood illusion, contributing to that signature pencil-shaving sharpness that makes this fragrance instantly recognizable.
Provides the mineral-flinty edge to the vetiver heart, creating that distinctive earthy-woody tension that defines this modern classic.
2D Molecular Structure
SMILES: CC1CC(CCC1=O)C1C2CCC(C2)C1(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
2-Methyl-4-(camphenyl-8)-cyclohexanone belongs to the bicyclic terpenoid ketone class, structurally related to camphor but with modified ring geometry that alters its olfactory properties. While not found in nature, it shares structural motifs with various terpenoids. Synthesis typically begins with camphene derivatives through controlled oxidation and rearrangement reactions. The methyl group at position 2 creates steric hindrance that affects volatility and odor characteristics.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Odor Strength | Medium to high |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody-modifier in masculine accords |
| Home Fragrance | 0.5-2% | Up to 3% | Adds dry woody character |
Classic Accords
Tip: Use to add dryness and lift to overly sweet woody compositions.
Alternatives & Comparisons
When a more diffusive, transparent woodiness is needed. Norlimbanol has higher volatility and less camphoraceous character.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA. No specific usage limits established.
RIFM Assessment
Not yet fully evaluated by RIFM. Considered low priority due to limited market presence.
Sustainability
As a synthetic material, this compound doesn’t rely on natural resource extraction. However, its production requires petrochemical feedstocks and energy-intensive processes. The fragrance industry is investigating greener synthesis routes to reduce environmental impact.
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Physicochemical Properties
DTXSID: DTXSID9052426
Physical Properties
| Molecular Weight | 234.383 g/mol🔬 EPA CompTox |
| Density | 0.975 g/cm^3📊 OPERA |
| Boiling Point | 315.738 °C📊 OPERA |
| Melting Point | 44.835 °C📊 OPERA |
| Flash Point | 134.958 °C📊 OPERA |
| Refractive Index | 1.496 Dimensionless📊 OPERA |
| Molar Volume | 240.22 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.223 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 4.223 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.223 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.37 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.001 mmHg📊 OPERA |
| Viscosity | 6.534 cP📊 OPERA |
| Surface Tension | 33.133 dyn/cm📊 OPERA |
| Thermal Conductivity | 109.397 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 70.209 cm^3/mol📊 OPERA |
| Polarizability | 27.833 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
