2-(Methylpropyl)quinoline (CAS 1333-58-0) — Woody Middle to base Note Fragrance Ingredient
2-(Methylpropyl)quinoline
CAS 1333-58-0
What Is 2-(Methylpropyl)quinoline?
2-(Methylpropyl)quinoline is a synthetic fragrance ingredient used in perfumery for its distinctive earthy, woody, and leathery character. It’s found in niche and designer fragrances, often in chypre and leather compositions. This molecule adds depth and complexity, mimicking natural oakmoss or tobacco notes while providing excellent stability and longevity in formulations.
Safety Profile
USE WITH AWARENESSWhat Does 2-(Methylpropyl)quinoline Smell Like?
2-(Methylpropyl)quinoline announces itself with a sharp, phenolic edge that quickly settles into a rich tapestry of aromas. Imagine the first whiff of a rare book’s leather binding, underscored by the damp earthiness of a forest floor after rain. As it evolves, the scent reveals smoky tobacco nuances and a faintly animalic muskiness reminiscent of well-worn suede. The dry-down lingers for hours, leaving an elegant trail of woody-ambery warmth with subtle green undertones that prevent it from becoming cloying.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to recreate the legendary Russian leather effect, providing the smoky birch tar alternative that’s more wearable in modern formulations while maintaining the fragrance’s iconic leather backbone.
Accents the leather accord with its phenolic sharpness, blending with birch tar and florals to create one of perfumery’s most authentic leather impressions.
Provides the daring, almost dangerous leathery growl that makes this fragrance legendary, contrasting sharply with the green galbanum top notes.
Used sparingly to add depth to the frankincense core, creating an impression of ancient parchment in this opulent oriental composition.
Modern overdose creates the fragrance’s signature ‘new car seat’ effect, amplified by raspberry to make the leather note more wearable.
Chemistry, Properties & Perfumer Guide
The Chemistry
2-(Methylpropyl)quinoline belongs to the quinoline class of heterocyclic compounds, characterized by a benzene ring fused to a pyridine ring. While quinolines occur naturally in some plants and animal secretions, this specific derivative is exclusively synthetic. Industrial synthesis typically involves the Skraup reaction, where aniline derivatives undergo condensation with glycerol in the presence of sulfuric acid and an oxidizing agent. The methylpropyl side chain at the 2-position provides volatility control and modulates the molecule’s olfactory profile. Unlike some quinolines, this derivative lacks strong fluorescence properties but exhibits excellent stability in both acidic and alkaline conditions.
Physical & Chemical Properties
| Appearance | Pale yellow to amber viscous liquid |
|---|---|
| Boiling Point | ~300 °C (estimated) |
| Density | ~1.05 g/cm³ (estimated) |
| Refractive Index | 1.58-1.62 (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Powerful modifier for leather accords |
| Home Fragrance | 0.05-0.2% | Up to 0.3% | Used sparingly in tobacco candles |
| Functional Products | 0.01-0.1% | Up to 0.15% | Masking agent for industrial odors |
Classic Accords
Tip: Balance with sweet vanillic notes to tame the phenolic sharpness in modern leather compositions.
Alternatives & Comparisons
More intense and greener, used when a sharper leather note is desired. Requires more careful dosing due to stronger diffusion.
Simpler structure with more pronounced chemical character, suitable for industrial applications where cost is a factor.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards. Listed on IFRA Transparency List with no usage limits specified.
EU Allergen Declaration
Not listed in EU allergen regulation (EC) No 1223/2009 Annex III.
GHS Classification
RIFM Assessment
RIFM has reviewed safety data for related quinoline derivatives but no specific assessment found for this compound. Considered safe at current usage levels.
Sustainability
As a synthetic material, 2-(Methylpropyl)quinoline doesn’t rely on natural resource extraction. Production typically uses petrochemical feedstocks, though modern green chemistry approaches are exploring bio-based aniline precursors. The molecule’s potency means very small quantities are needed, reducing overall environmental impact compared to some natural alternatives like oakmoss.
Explore 2-(Methylpropyl)quinoline
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
- Arctander, S. (1969). Perfume and Flavor Chemicals. Montclair, NJ.
- Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data error
