2-sec-Butylcyclohexanone (CAS 14765-30-1) — Woody Base Note Fragrance Ingredient
2-sec-Butylcyclohexanone
CAS 14765-30-1
What Is 2-sec-Butylcyclohexanone?
2-sec-Butylcyclohexanone is a synthetic fragrance ingredient used to add woody, slightly musky notes to perfumes. It is often found in modern masculine fragrances and body care products. This ingredient helps create depth and longevity in scents, making it valuable for perfumers aiming for sophisticated, long-lasting compositions.
Safety Profile
GENERALLY SAFEWhat Does 2-sec-Butylcyclohexanone Smell Like?
2-sec-Butylcyclohexanone opens with a clean, woody aroma reminiscent of freshly cut cedar, subtly underpinned by a musky warmth. Over time, the scent evolves into a smoother, slightly sweet base note, blending seamlessly with other ingredients to enhance complexity and staying power. Its dry-down is elegant and understated, perfect for adding a refined touch to fragrances.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the woody, masculine character, providing depth and longevity in this modern classic.
Adds a subtle woody-musky nuance to the fresh, aromatic composition.
2D Molecular Structure
SMILES: CCC(C)C1CCCCC1=O
Chemistry, Properties & Perfumer Guide
The Chemistry
2-sec-Butylcyclohexanone is a synthetic ketone derived from cyclohexanone. It is produced through alkylation reactions, often using sec-butyl groups. Its structure allows for good stability and compatibility with a wide range of fragrance ingredients, making it a versatile choice for perfumers.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Adds woody depth |
| Body Care | 0.5-2% | Up to 5% | Enhances longevity |
Classic Accords
Tip: Use in moderation to avoid overpowering other notes.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply.
RIFM Assessment
RIFM safety assessment confirms it is safe for use in current concentrations.
Sustainability
As a synthetic ingredient, 2-sec-Butylcyclohexanone is produced in controlled environments, minimizing environmental impact. Its consistent quality and availability make it a reliable choice for sustainable fragrance development.
Explore 2-sec-Butylcyclohexanone
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References
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID4041818
Physical Properties
| Molecular Weight | 154.253 g/mol🔬 EPA CompTox |
| Density | 0.914 g/cm^3🔬 EPA CTX |
| Boiling Point | 221 °C🔬 EPA CTX |
| Melting Point | 20.779 °C📊 OPERA |
| Flash Point | 87 °C🔬 EPA CTX |
| Refractive Index | 1.452 Dimensionless📊 OPERA |
| Molar Volume | 171.568 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.159 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.159 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.159 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 5 Log10 unitless📊 OPERA |
| Water Solubility | 0.004 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 4.692 mmHg🔬 EPA CTX |
| Viscosity | 2.138 cP📊 OPERA |
| Surface Tension | 30.387 dyn/cm📊 OPERA |
| Thermal Conductivity | 128.389 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 2 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 46.298 cm^3/mol📊 OPERA |
| Polarizability | 18.354 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
