3,5,6,6-Tetramethyl-4-methyleneheptan-2-ol (CAS 81787-06-06) — Woody Middle to Base Note Fragrance Ingredient
3,5,6,6-Tetramethyl-4-methyleneheptan-2-ol
CAS 81787-06-06
What Is 3,5,6,6-Tetramethyl-4-methyleneheptan-2-ol?
3,5,6,6-Tetramethyl-4-methyleneheptan-2-ol is a synthetic fragrance ingredient used to add woody, amber-like nuances to perfumes. It’s found in modern designer fragrances and personal care products. This molecule helps create depth and longevity in scents, often blending with floral and citrus notes to enhance complexity without overpowering.
Safety Profile
GENERALLY SAFEWhat Does 3,5,6,6-Tetramethyl-4-methyleneheptan-2-ol Smell Like?
This synthetic alcohol delivers a crisp, woody character with subtle amber undertones. Initially presenting a clean, slightly metallic sharpness, it evolves into a dry woody heart with faintly sweet, resinous facets. The dry-down reveals a smooth, almost musky base note that lingers close to the skin. Imagine the scent of freshly planed cedarwood meeting the faintest whisper of vanilla-infused amber.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a woody-amber modifier to enhance the fragrance’s modern freshness, adding depth to the bergamot top notes and blending seamlessly with the ambroxan base.
Employed in the woody accord to bridge citrus top notes with incense-like base, contributing to the fragrance’s polished masculine character.
Chemistry, Properties & Perfumer Guide
The Chemistry
3,5,6,6-Tetramethyl-4-methyleneheptan-2-ol is a branched-chain tertiary alcohol with a tetrasubstituted double bond. Its synthesis typically involves Grignard reactions or hydroformylation of appropriate terpene precursors. The sterically hindered structure contributes to its stability and slow evaporation rate. While purely synthetic in commercial use, structurally similar compounds can be found as minor components in some essential oils.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | Estimated 230-250°C |
| Density | Estimated 0.89-0.92 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Woody accord enhancer |
| Personal Care | 0.5-1.5% | Up to 2% | Adds subtle warmth |
Classic Accords
Tip: Use with citrus top notes to prevent the woody character from becoming too heavy.
Alternatives & Comparisons
When a more diffusive, transparent woody effect is desired with less amber character.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
RIFM Assessment
Under review by RIFM for comprehensive safety assessment.
Sustainability
As a synthetic material, this ingredient avoids natural resource depletion. Production typically uses petrochemical feedstocks, though some manufacturers are exploring bio-based routes. Energy efficiency in synthesis is improving with catalytic process optimizations.
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References
- Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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