6-Butyl-2,4-dimethyldihydropyrane (CAS 24237-00-1) — Woody Middle to base Note Fragrance Ingredient

ByThe Good Scents
Woody · Spicy

6-Butyl-2,4-dimethyldihydropyrane

CAS 24237-00-1

Origin
synthetic
Note
Middle to base
IFRA
Generally safe
Data as of: Apr 2026

What Is 6-Butyl-2,4-dimethyldihydropyrane?

6-Butyl-2,4-dimethyldihydropyrane is a synthetic fragrance compound used to add woody, spicy nuances to perfumes and scented products. You’ll encounter it in premium fragrances and home care products where warm, complex notes are desired. This ingredient matters because it helps perfumers create depth and longevity in modern scent compositions, bridging fresh top notes with richer base accords.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major restrictions
⚠ Limited safety data – use standard precautions
CAS
24237-00-1
Formula
Mixture
MW
Variable
Odor Family
Woody · Spicy
Layer 1 · Enthusiast

What Does 6-Butyl-2,4-dimethyldihydropyrane Smell Like?

6-Butyl-2,4-dimethyldihydropyrane unfolds with an initial burst of peppery warmth, like black pepper crushed over aged cedar. The heart reveals a sophisticated woody-spicy character reminiscent of sandalwood shavings dusted with nutmeg. As it dries down, it leaves a subtle leathery trail with whispers of dried tobacco leaves. The overall effect is warm, slightly sweet, and remarkably tenacious – a molecule that behaves like a chameleon, amplifying woody bases while adding dimensionality to spicy top notes.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Spicebomb(Viktor&Rolf, 2012)

Used as a woody-spicy bridge between the citrus top and vanilla base, adding masculine warmth without overwhelming sweetness.

Terre d'Hermès(Hermès, 2006)

Provides subtle peppery facets that complement the flinty mineral accord, creating depth in the woody heart.

Layer 2

2D Molecular Structure

6-Butyl-2,4-dimethyldihydropyrane

SMILES: CCCCC1OC(C)CC(C)=C1

Chemistry, Properties & Perfumer Guide

The Chemistry

6-Butyl-2,4-dimethyldihydropyrane belongs to the dihydropyran class of heterocyclic compounds. While not found in nature, its structure mimics certain woody-spicy molecules found in essential oils. Synthesized through acid-catalyzed cyclization of appropriate diketones, this chiral molecule exists as enantiomers that may show odor differences. The butyl side chain contributes to its tenacity and woody character, while the methyl groups moderate its volatility.

Physical & Chemical Properties

AppearanceColorless to pale yellow liquid
Boiling PointApprox. 220-230 °C (estimated)
Density~0.89 g/cm³ (estimated)

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-4 hours)
Blending
Good with woods and spices
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Woody-spicy modifier
Home Fragrance0.5-2%Up to 3%Adds warmth to diffuser blends

Classic Accords

Tip: Use sparingly in oriental compositions to add peppery complexity without overwhelming sweeter notes.

Alternatives & Comparisons

1
Isobutyl quinoline CAS 65442-31-1

For more leathery effects at similar usage levels, though with less spice and more animalic character.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No current IFRA restrictions.

RIFM Assessment

Not currently evaluated by RIFM – considered low priority due to limited use volume.

Sustainability

As a synthetic material, 6-Butyl-2,4-dimethyldihydropyrane has minimal environmental impact in production compared to natural extracts. Its efficient synthesis from petrochemical precursors results in consistent quality without seasonal variation or agricultural land use. The molecule’s potency allows for low usage levels, reducing overall environmental load in finished products.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 24237-00-1

    Physical Properties

    Molecular Weight168.28 g/mol🔬 PubChem
    LogP (Octanol-Water)2.9🔬 PubChem
    Boiling Point215 °C🔬 EPA CompTox
    Vapor Pressure0.2818 mmHg @ 25°C📊 OPERA
    Flash Point81.1 °C🔬 EPA CompTox
    Involatility Index0.0234💻 Calculated
    log Kp (skin permeability)-1.668💻 Calculated
    SMILESCCCCC1C=C(CC(O1)C)C🔬 PubChem

    Volatility & Performance

    Fragrance NoteHeart💻 Calculated
    Volatility ClassSlow💻 Calculated
    Persistence Score1 / 5💻 Calculated

    Odor & Flavor

    Primary Descriptorsspicywoody• leffingwell
    Functional Groupsetheralkene💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID7051898

    Physical Properties

    Molecular Weight 168.28 g/mol🔬 EPA CompTox
    Density 0.869 g/cm^3📊 OPERA
    Boiling Point 213.553 °C📊 OPERA
    Melting Point -38.69 °C📊 OPERA
    Flash Point 78.084 °C📊 OPERA
    Refractive Index 1.437 Dimensionless📊 OPERA
    Molar Volume 199.352 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 4.385 Log10 unitless📊 OPERA
    LogD (pH 5.5) 4.385 Log10 unitless📊 OPERA
    LogD (pH 7.4) 4.385 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 5.18 Log10 unitless📊 OPERA
    Water Solubility 0.003 mol/L📊 OPERA
    Henry's Law Constant 0.001 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.303 mmHg📊 OPERA
    Viscosity 2.067 cP📊 OPERA
    Surface Tension 25.399 dyn/cm📊 OPERA
    Thermal Conductivity 125.369 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 9.23 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 3 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 52.272 cm^3/mol📊 OPERA
    Polarizability 20.722 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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