Citronelloxyacetaldehyde (CAS 7492-67-3) — Citrus Top to middle Note Fragrance Ingredient
Citronelloxyacetaldehyde
CAS 7492-67-3
What Is Citronelloxyacetaldehyde?
Citronelloxyacetaldehyde is a synthetic fragrance ingredient used to add fresh, citrusy-green notes to perfumes and scented products. You’ll encounter it in air fresheners, fabric softeners, and some citrus-forward perfumes. This molecule matters because it bridges citrus and floral accords, helping create lifelike citrus top notes that don’t fade too quickly. Its balanced profile makes it versatile for both masculine and feminine fragrances.
Safety Profile
USE WITH AWARENESSWhat Does Citronelloxyacetaldehyde Smell Like?
Citronelloxyacetaldehyde bursts with a vibrant citrus-green character reminiscent of freshly crushed lemongrass, evolving into a softer floral-herbal heart. Imagine peeling a ripe grapefruit next to a pot of flowering geraniums. The dry-down reveals a clean, slightly woody undertone that prevents the citrus from becoming too sharp or fleeting. Unlike simpler citrus notes, this molecule maintains dimensionality for hours, transitioning smoothly into floral bases without losing its fresh identity.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to amplify the energizing citrus opening while providing bridge notes to the floral heart. The molecule’s green facets complement the mint and herbal elements.
Contributes to the sparkling Mediterranean citrus accord, helping blend lemon top notes with jasmine heart notes through its floral-citrus duality.
2D Molecular Structure
SMILES: CC(CCOCC=O)CCC=C(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
Citronelloxyacetaldehyde belongs to the acetaldehyde class, specifically a citronellol-derived oxyacetaldehyde. As a synthetic material, it’s typically produced through controlled oxidation of citronellol or condensation reactions with glycols. The molecule’s aldehyde group is responsible for its fresh top notes, while the citronellol-derived chain provides floral-green character. Its stability in ethanol solutions makes it particularly useful for fine fragrance applications.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Solubility | Soluble in alcohol and oils |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Citrus-floral bridge |
| Functional Products | 0.1-0.5% | Up to 1% | Freshness booster |
Classic Accords
Tip: Use with ionones to create seamless citrus-floral transitions.
Alternatives & Comparisons
When more floral character is desired with less citrus sharpness. Also more stable in alkaline formulations.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under IFRA 51st Amendment. General aldehyde precautions apply.
GHS Classification
RIFM Assessment
RIFM assessment complete – safe at current use levels with proper precautions.
Sustainability
As a synthetic material, citronelloxyacetaldehyde production avoids agricultural impacts. Modern manufacturing processes minimize solvent use and energy consumption. Being highly potent reduces the required quantity per formulation.
Explore Citronelloxyacetaldehyde
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References
- Bauer et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 7492-67-3Physical Properties
| Molecular Weight | 198.3 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 3.3🔬 PubChem |
| Boiling Point | 130 °C🔬 EPA CompTox |
| log Kp (skin permeability) | -1.567💻 Calculated |
| SMILES | CC(CCC=C(C)C)CCOCC=O🔬 PubChem |
Volatility & Performance
| Fragrance Note | Top💻 Calculated |
Odor & Flavor
| Primary Descriptors | citrusfloralmelonrose• leffingwell |
| Functional Groups | aldehydeetheralkene💻 RDKit |
| “Powerful and moderately diffusive green-rosy, sweet Lily-Muguet-like odor. Its tenacity is comparatively good.”📖 Arctander | |
| Citronellyl oxyacetaldehyde has a strong, rose odor. -📖 Fenaroli | |
Flavor Notes (Arctander)
| “Occasionally used in flavor compositions for floral or fruity types, and in Rose type flavors. The concentration is usually mere traces in the finished product.”📖 Arctander |
Regulatory Status
| IOFI Classification | Artificial📖 Fenaroli |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID7052492
Physical Properties
| Molecular Weight | 198.306 g/mol🔬 EPA CompTox |
| Density | 0.922 g/cm^3🔬 EPA CTX |
| Boiling Point | 249.841 °C📊 OPERA |
| Melting Point | -33.555 °C📊 OPERA |
| Flash Point | 94.933 °C📊 OPERA |
| Refractive Index | 1.443 Dimensionless📊 OPERA |
| Molar Volume | 224.09 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.26 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.593 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.593 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.12 Log10 unitless📊 OPERA |
| Water Solubility | 0.002 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.025 mmHg📊 OPERA |
| Viscosity | 2.416 cP📊 OPERA |
| Surface Tension | 27.073 dyn/cm📊 OPERA |
| Thermal Conductivity | 139.923 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 26.3 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 8 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 59.435 cm^3/mol📊 OPERA |
| Polarizability | 23.562 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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