Diisobutyl adipate (CAS 0141-04-08) — Sweet Base Note Fragrance Ingredient
Diisobutyl adipate
CAS 0141-04-08
What Is Diisobutyl adipate?
Diisobutyl adipate is a synthetic ester commonly used as a solvent and fixative in perfumes and cosmetics. It helps blend fragrance oils while reducing greasiness. This ingredient matters because it improves product texture and extends scent longevity without adding its own strong odor, making it a versatile tool for perfumers.
Safety Profile
GENERALLY SAFEWhat Does Diisobutyl adipate Smell Like?
Diisobutyl adipate is nearly odorless with just a faint, clean ester-like character reminiscent of diluted pear drops. It serves primarily as a neutral carrier that doesn’t interfere with fragrance compositions. The complete lack of top notes makes it ideal for stabilizing volatile components without shifting accords.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a solvent for galbanum and green notes to prevent separation while maintaining crispness.
Helps suspend citrus top notes longer without the oiliness that would dull their sparkle.
Chemistry, Properties & Perfumer Guide
The Chemistry
Diisobutyl adipate belongs to the ester class, formed by esterification of adipic acid with isobutanol. As a diester, it has excellent solvent properties for both polar and non-polar fragrance materials. Industrial synthesis typically involves acid-catalyzed reactions under controlled temperature conditions to maximize yield.
Physical & Chemical Properties
| Boiling Point | 298-300 °C |
|---|---|
| Flash Point | >110 °C |
| Density | 0.95 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 5-15% | Up to 25% | Solvent/fixative |
| Cosmetics | 3-10% | Up to 20% | Emollient carrier |
Classic Accords
Tip: Use to replace DPG in alcohol-based perfumes for better oil solubility.
Alternatives & Comparisons
Higher boiling point alternative with similar solvent properties but slightly fruitier odor.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions – listed as safe for all applications.
RIFM Assessment
RIFM assessment confirms safe use current levels.
Sustainability
Synthesized from petrochemical feedstocks but requires minimal processing energy. Not biodegradable – proper disposal required.
Explore Diisobutyl adipate
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References
- Fiume et al. (2014). Safety Assessment of Diisobutyl Adipate. International Journal of Toxicology. PMID 24789603
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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