Indeno[4,5-d]-1,3-dioxin,4,4a,5,6,7,8,9,9b-octahydro-7,7,8,9,9-pentamethyl- (CAS 365411-50-3) — Woody Middle Note Fragrance Ingredient

Woody · Balsamic

Indeno[4,5-d]-1,3-dioxin,4,4a,5,6,7,8,9,9b-octahydro-7,7,8,9,9-pentamethyl-

CAS 365411-50-3

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is Indeno[4,5-d]-1,3-dioxin,4,4a,5,6,7,8,9,9b-octahydro-7,7,8,9,9-pentamethyl-?

This synthetic fragrance ingredient is used in modern perfumery to create unique scent profiles. While not commonly recognized by name, it contributes to complex fragrance compositions. Its importance lies in providing perfumers with novel olfactory tools that can’t be found in nature, allowing for innovative scent creations that push the boundaries of traditional perfumery.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
No major safety concerns reported
Limited safety data available
CAS
365411-50-3
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does Indeno[4,5-d]-1,3-dioxin,4,4a,5,6,7,8,9,9b-octahydro-7,7,8,9,9-pentamethyl- Smell Like?

This synthetic molecule offers a complex olfactory profile that evolves subtly on the skin. Initially presenting with crisp, slightly woody undertones, it develops into a more rounded, ambery character during the dry-down. The scent has a modern, almost futuristic quality – clean yet mysterious, with hints of polished metal and warm resins that create intriguing contrasts.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

Indeno[4,5-d]-1,3-dioxin derivatives represent a class of synthetic fragrance compounds designed for their stability and unique olfactory properties. The pentamethyl substitution pattern on this particular derivative contributes to its volatility profile and scent characteristics. These molecules are typically synthesized through complex cyclization reactions of appropriate precursors, often involving catalytic processes to achieve the desired stereochemistry.

Physical & Chemical Properties

Perfumer Guide

Note Position
Middle
Volatility
Moderate (2-6 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Used as a modern woody-amber modifier
Functional Fragrance0.1-0.5%Up to 1%Adds depth to cleaning products

Classic Accords

Tip: Use as a bridge note to connect fresh top notes with deeper base materials.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

Offers similar amber characteristics but with more diffusion and less woody nuance.

2
Cashmeran CAS 33704-61-9

Provides woody-musky facets that complement this material’s profile.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No IFRA restrictions currently apply to this material.

RIFM Assessment

Full safety assessment not yet completed by RIFM.

Sustainability

As a synthetic material, this compound avoids natural resource depletion concerns. However, its complex synthesis requires careful consideration of green chemistry principles to minimize environmental impact. The fragrance industry continues to evaluate such novel synthetics for their sustainability profile throughout their lifecycle.

Explore Indeno[4,5-d]-1,3-dioxin,4,4a,5,6,7,8,9,9b-octahydro-7,7,8,9,9-pentamethyl-

Browse essential oils and aroma compounds.

Browse on iHerb →

Affiliate disclosure: we may earn a small commission at no extra cost to you.

References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Similar Posts