Phenol, 3-methyl-4-(1-methylethyl)- (CAS 3228-02-02) — Woody Heart to base Note Fragrance Ingredient
Phenol, 3-methyl-4-(1-methylethyl)-
CAS 3228-02-02
What Is Phenol, 3-methyl-4-(1-methylethyl)-?
Phenol, 3-methyl-4-(1-methylethyl)- is a synthetic aromatic compound used in fragrances for its warm, woody-spicy character. It’s found in niche perfumes and specialty formulations. This ingredient matters because it adds depth and complexity to woody accords, often serving as a bridge between top and heart notes.
Safety Profile
USE WITH AWARENESSWhat Does Phenol, 3-methyl-4-(1-methylethyl)- Smell Like?
A dense, phenolic warmth with echoes of birch tar and smoked woods. Opens with a medicinal sharpness that quickly mellows into leathery depths. The dry-down reveals subtle vanillic undertones and a lingering skin-like muskiness that behaves like well-worn suede.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to recreate the historic Russian leather accord, providing the authentic birch tar smokiness that defines this legendary fragrance.
This phenol derivative contributes to the vintage leather glove effect, blending with castoreum and florals for a rugged yet refined masculine statement.
Chemistry, Properties & Perfumer Guide
The Chemistry
A substituted phenol with isopropyl and methyl groups creating steric hindrance that modifies its reactivity. Synthesized through Friedel-Crafts alkylation of cresols. The ortho-substitution pattern lends unique stability while the phenolic OH remains available for hydrogen bonding.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | 230-235°C |
| Density | 0.98-1.02 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Leather Accords | 0.5-2% | Up to 3.5% | Provides authentic smoky leather character |
| Fougères | 0.1-0.8% | Up to 1.2% | Adds phenolic complexity to lavender-oakmoss structures |
Classic Accords
Tip: Always pre-dilute to 10% in ethanol before blending to ensure even distribution.
Alternatives & Comparisons
When a softer, more vanillic phenolic character is desired without the harsh medicinal top notes.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
IFRA restricted under Amendment 49 – maximum 0.2% in leave-on products due to sensitization potential.
EU Allergen Declaration
Not currently listed as EU allergen.
GHS Classification
RIFM Assessment
Under review by RIFM for updated safety assessment.
Sustainability
Synthesized from petrochemical precursors with moderate environmental impact. No known natural sources. Process optimization can reduce energy consumption during production.
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References
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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