Pyridine, 5-hexyl-2-methyl- (CAS 710-40-7) — Balsamic Middle Note Fragrance Ingredient
Pyridine, 5-hexyl-2-methyl-
CAS 710-40-7
What Is Pyridine, 5-hexyl-2-methyl-?
Pyridine, 5-hexyl-2-methyl- is a synthetic aroma chemical used in niche fragrances to add leathery, smoky nuances. It’s found in avant-garde perfumes seeking unconventional effects. This molecule matters because it provides perfumers with a unique tool to create modern, edgy accords that push beyond traditional fragrance boundaries.
Safety Profile
USE WITH AWARENESSWhat Does Pyridine, 5-hexyl-2-methyl- Smell Like?
A sharp, pungent opening evolves into a complex leathery-smoky heart with animalic undertones. The dry-down reveals a persistent, slightly medicinal character reminiscent of aged tobacco and cured hides. Its metallic edge cuts through sweeter notes like a knife through butter, making it ideal for modern leather accords.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used sparingly to enhance the authentic birch tar leather accord, adding depth and modernity to this classic composition.
Provides the raw, unfinished leather character that makes this fragrance so distinctive and contemporary.
Chemistry, Properties & Perfumer Guide
The Chemistry
This pyridine derivative belongs to the heterocyclic nitrogen-containing compounds class. Synthesized through alkylation reactions of pyridine precursors, its structure features a hexyl side chain that contributes to its hydrophobic character. The methyl group at position 2 influences its volatility and odor profile. The nitrogen atom creates a dipole moment that affects its interaction with olfactory receptors.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Used sparingly for leather effects |
| Functional Fragrance | 0.01-0.1% | Up to 0.2% | Masking agent in industrial applications |
Classic Accords
Tip: Use in trace amounts and balance with softer materials to avoid overwhelming compositions.
Alternatives & Comparisons
Less aggressive alternative for leather accords with similar functionality but smoother profile.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific IFRA restrictions currently apply to this material.
GHS Classification
RIFM Assessment
Currently under review by RIFM for comprehensive safety assessment.
Sustainability
As a synthetic material, production involves petrochemical feedstocks but requires relatively low energy inputs compared to natural alternatives. Its potency means small quantities suffice, reducing overall environmental impact per kilogram of fragrance produced.
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References
- Burdock, G.A. (2010). Fenaroli’s Handbook of Flavor Ingredients. CRC Press.
- Arctander, S. (1969). Perfume and Flavor Chemicals. Allured Publishing.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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