Thibetolide (CAS 6707-60-4) — Musky Base Note Fragrance Ingredient
Thibetolide
CAS 6707-60-4
What Is Thibetolide?
Thibetolide is a synthetic musk used in perfumery to add depth and warmth. Consumers encounter it in high-end fragrances where it contributes to long-lasting, sensual base notes. Its importance lies in its ability to mimic rare animal musks without ethical concerns, providing a clean alternative for modern perfumery.
Safety Profile
GENERALLY SAFEWhat Does Thibetolide Smell Like?
Thibetolide offers a rich, velvety musk with subtle animalic undertones, reminiscent of sun-warmed skin. It evolves slowly on the skin, starting with a slightly powdery aura that deepens into a creamy, intimate trail. Unlike sharp synthetic musks, it carries a rounded sophistication akin to cashmere fabric – soft yet persistently noticeable.
Scent Profile
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Thibetolide provides the crucial modern musk foundation that balances this fragrance’s animalic notes, creating a wearable interpretation of historic musk compositions.
Used here to amplify the musk accord while maintaining cleanliness standards, demonstrating its versatility in both niche and mass-market applications.
2D Molecular Structure
SMILES: O=C1CCCCCCCCCCOCCCCO1
Chemistry, Properties & Perfumer Guide
The Chemistry
Thibetolide belongs to the macrocyclic musk family, characterized by large ring structures (typically 15-17 atoms) that mimic natural musk compounds. Modern synthesis begins with long-chain fatty acids, employing ring-closing metathesis for efficient cyclization. Unlike early nitro musks, these macrocyclics exhibit excellent stability and biodegradability.
Physical & Chemical Properties
| Molecular Weight | Not specified |
|---|---|
| Boiling Point | Not specified |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Provides lasting power |
| Body Care | 0.5-1% | Up to 2% | Skin-safe concentrations |
Classic Accords
Tip: Use with ionones to create seamless floral-musk transitions.
Alternatives & Comparisons
When a lighter, more diffusive musk is needed. Shares similar blending properties but with higher volatility.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. IFRA, REACH, EU Cosmetics Regulation standards update periodically. Consult current IFRA Standards Library before formulating. Not legal or regulatory advice.
IFRA Status
No restrictions under current IFRA standards (as of Amendment 49).
EU Allergen Declaration
Not listed as EU allergen.
RIFM Assessment
RIFM safety assessment confirms safe use at current industry levels.
Sustainability
As a synthetic musk, Thibetolide reduces pressure on natural resources while avoiding animal-derived ingredients. Modern production methods prioritize atom economy and reduced solvent use compared to early musk syntheses.
Explore Thibetolide
Browse essential oils and aroma compounds.
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References
- IFRA Standards Library (2023) IFRA
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Mar 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID4047705
Physical Properties
| Molecular Weight | 256.386 g/mol🔬 EPA CompTox |
| Density | 0.983 g/cm^3🔬 EPA CTX |
| Boiling Point | 351 °C🔬 EPA CTX |
| Melting Point | -27.1 °C🔬 EPA CTX |
| Flash Point | 171.667 °C🔬 EPA CTX |
| Refractive Index | 1.431 Dimensionless📊 OPERA |
| Molar Volume | 280.158 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.67 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.67 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.67 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 8.98 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg🔬 EPA CTX |
| Viscosity | 5.575 cP📊 OPERA |
| Surface Tension | 28.482 dyn/cm📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 35.53 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 3 count💻 Computed |
| Rotatable Bonds | 0 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 72.517 cm^3/mol📊 OPERA |
| Polarizability | 28.748 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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