1,3-Dioxane, 5-methyl-2-(2-methylpropyl)-cis- (CAS 166301-22-0) — Green Middle Note Fragrance Ingredient

Green · Woody

1,3-Dioxane, 5-methyl-2-(2-methylpropyl)-cis-

CAS 166301-22-0

Origin
synthetic
Note
Middle
IFRA
Use with awareness
Data as of: Apr 2026

What Is 1,3-Dioxane, 5-methyl-2-(2-methylpropyl)-cis-?

This synthetic fragrance molecule is a specialized ingredient used by perfumers to create unique effects in modern perfumery. While not found in nature, it contributes to complex scent profiles in high-end fragrances. It matters because such molecules allow perfumers to craft novel olfactory experiences that can’t be achieved with natural materials alone, pushing the boundaries of modern perfumery.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
Used in professional perfumery
Limited safety data available
CAS
166301-22-0
Formula
Mixture
MW
Variable
Odor Family
Green · Woody
Layer 1 · Enthusiast

What Does 1,3-Dioxane, 5-methyl-2-(2-methylpropyl)-cis- Smell Like?

This synthetic molecule offers a clean, slightly green character with subtle woody undertones. It presents a crisp opening that evolves into a more rounded, slightly sweet heart. The dry-down reveals a faintly musky character, making it useful for adding subtle complexity to modern compositions. Its odor profile has been described as reminiscent of freshly cut grass with a whisper of damp earth.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

1,3-Dioxane derivatives are cyclic acetals formed from the reaction of aldehydes or ketones with diols. The 5-methyl-2-(2-methylpropyl) substitution pattern in this particular derivative creates unique steric and electronic effects that influence its odor profile. These compounds are typically synthesized through acid-catalyzed condensation reactions. The cis configuration of the substituents may influence both the volatility and odor characteristics of the molecule.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Middle
Volatility
Moderate (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Used as a modifier
Functional Fragrance0.1-1%Up to 3%For subtle green effects

Classic Accords

Tip: Use sparingly to add green freshness without overpowering the composition.

Alternatives & Comparisons

1
Stemone CAS 63835-76-1

Offers similar green character but with more pronounced stem-like qualities.

2
Verdox CAS 88-41-5

Provides a cleaner, more intense green apple note when fresher effects are desired.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

No formal RIFM assessment found for this specific compound.

Sustainability

As a synthetic material, this compound’s environmental impact depends on the manufacturing process and raw material sourcing. Being produced in controlled laboratory settings typically results in more consistent quality and potentially lower ecological impact compared to some natural material extraction methods. However, full life cycle assessments for this specific molecule are not publicly available.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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