1,3-Dioxolane, 2,4-dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-, trans- (CAS 131812-52-7) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Green

1,3-Dioxolane, 2,4-dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-, trans-

CAS 131812-52-7

Origin
synthetic
Note
Middle
IFRA
Professional use
Data as of: Apr 2026

What Is 1,3-Dioxolane, 2,4-dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-, trans-?

This synthetic fragrance ingredient is a specialized chemical compound primarily used by professional perfumers to create unique scent profiles. It’s not commonly encountered in everyday products but may appear in niche or experimental fragrances. The ingredient contributes woody, ambery nuances with subtle green undertones, making it valuable for creating complex, modern accords that evolve intriguingly on skin.

Safety Profile

PROFESSIONAL USE
Generally safeUse with awarenessProfessional use
⚠ Limited safety data available
⚠ Professional handling recommended
CAS
131812-52-7
Formula
Mixture
MW
Variable
Odor Family
Woody · Green
Layer 1 · Enthusiast

What Does 1,3-Dioxolane, 2,4-dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-, trans- Smell Like?

This synthetic molecule presents an intriguing duality – opening with crisp, almost ozonic green facets that recall crushed stems and fresh rainfall. Within minutes, it transitions to reveal a sophisticated woody-ambergris heart with subtle tobacco-like richness. The dry-down lingers as a skin-hugging musk with whispers of sun-warmed driftwood and just a ghost of camphoraceous coolness, creating remarkable tenacity for a synthetic material.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

1,3-Dioxolane derivatives represent a class of cyclic acetals known for their stability and versatile olfactory properties. This particular substituted dioxolane features a tetramethyltetralin moiety that contributes to its woody-ambergris character. Synthesized through acid-catalyzed condensation reactions, these compounds demonstrate how strategic molecular architecture can create novel scent profiles not found in nature. The trans configuration of this isomer is particularly prized for its superior odor characteristics and persistence.

Physical & Chemical Properties

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good for woody bases
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Used as woody-amber modifier
Functional Fragrance0.1-0.5%Up to 1%Limited use due to cost

Classic Accords

Tip: Best incorporated during the heart phase to bridge top and base notes.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

Provides similar ambery-woody effects but with less green character and better safety profile.

2
Norlimbanol CAS 70788-30-6

Offers more pronounced woody notes but lacks the subtle green facets of the original compound.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions, but falls under general guidelines for synthetic ingredients (Amendment 49).

RIFM Assessment

Not currently assessed by RIFM due to limited commercial use.

Sustainability

As a synthetic material, this compound avoids natural resource depletion but requires energy-intensive manufacturing. The complex synthesis pathway may involve multiple purification steps, impacting its environmental footprint. Future green chemistry approaches could potentially improve its sustainability profile.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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