2-Cyclohexen-1-one, 4-[3-(acetyloxy)-1-buten-1-yl]-3,5,5-trimethyl-, pyrolyzed (CAS 163440-97-9) — Woody Middle to base Note Fragrance Ingredient

Woody · Sweet

2-_Cyclohexen-_1-_one, 4-_[3-_(acetyloxy)_-_1-_buten-_1-_yl]_-_3,_5,_5-_trimethyl-_, pyrolyzed

CAS 163440-97-9

Origin
synthetic
Note
Middle to base
IFRA
Professional use
Data as of: Apr 2026

What Is 2-_Cyclohexen-_1-_one, 4-_[3-_(acetyloxy)_-_1-_buten-_1-_yl]_-_3,_5,_5-_trimethyl-_, pyrolyzed?

This synthetic fragrance ingredient is a specialized chemical used in modern perfumery to create unique olfactory effects. It’s found in avant-garde and niche fragrances pushing creative boundaries. While not commonly encountered by consumers, it represents perfumers’ ability to engineer novel scent molecules that don’t exist in nature.

Safety Profile

PROFESSIONAL USE
Generally safeUse with awarenessProfessional use
Limited safety data available
Requires professional handling
CAS
163440-97-9
Formula
Mixture
MW
Variable
Odor Family
Woody · Sweet
Layer 1 · Enthusiast

What Does 2-_Cyclohexen-_1-_one, 4-_[3-_(acetyloxy)_-_1-_buten-_1-_yl]_-_3,_5,_5-_trimethyl-_, pyrolyzed Smell Like?

This synthetic molecule offers a complex olfactory profile with woody-ambery facets layered over a burnt sugar character. The acetyloxy butenyl side chain contributes a surprising fruity-sweet nuance that evolves into smoky, almost tar-like undertones during dry-down. Imagine charred maple wood drizzled with caramel that gradually reveals an industrial rubber note – challenging yet intriguing for experimental compositions.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

This cyclohexenone derivative features an acetyloxy-substituted butenyl side chain at the 4-position, creating a hybrid structure combining cyclic ketone and ester functionalities. The trimethyl substitution pattern enhances molecular stability while influencing volatility. Synthesis typically involves condensation reactions of pre-functionalized cyclohexenone precursors with appropriate acetyloxy butenyl reagents, followed by pyrolysis to develop the characteristic smoky facets.

Physical & Chemical Properties

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-6 hours)
Blending
Challenging
ApplicationTypical %RangeNotes
Fine Fragrance0.1-0.5%Up to 1%Used as an effect material
Functional FragranceNot usedN/AToo specialized

Classic Accords

Tip: Use micro-doses in woody-amber bases to add dimensionality without overwhelming the composition.

Alternatives & Comparisons

1
Trimethyl cyclohexenone CAS 78-59-1

Simpler analogue with similar woody character but lacking the complex pyrolysis effects.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA. No specific usage limits established.

RIFM Assessment

No RIFM assessment available due to specialized usage.

Sustainability

As a synthetic material, production avoids natural resource depletion but requires energy-intensive chemical processes. The specialized nature means production volumes are low, minimizing environmental impact. Future green chemistry approaches could potentially improve synthesis routes.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 163440-97-9
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

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