1,4-Cineole (CAS 470-67-7) — Green Top Note Fragrance Ingredient
1,4-Cineole
CAS 470-67-7
What Is 1,4-Cineole?
1,4-Cineole is a synthetic fragrance ingredient that creates fresh, camphoraceous aromas. It’s often used in cleaning products and masculine fragrances for its crisp, medicinal character. This molecule matters because it adds a distinctive ‘cooling’ effect to scents, mimicking natural eucalyptus without the harshness of some essential oils.
Safety Profile
GENERALLY SAFEWhat Does 1,4-Cineole Smell Like?
1,4-Cineole bursts with a sharp, medicinal freshness reminiscent of crushed eucalyptus leaves and wintergreen. The initial blast carries an almost menthol-like chill that gradually softens into a cleaner, woody-herbal character. Unlike its 1,8-cineole counterpart, it lacks the harsh camphor edge, developing instead into a smoother, more diffusive aroma with subtle floral undertones that emerge during dry-down.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used sparingly to enhance the citrus-herbal freshness, contributing to the fragrance’s signature ‘barbershop’ crispness without overpowering the delicate citrus notes.
Provides a subtle cooling effect that complements the aquatic accord, adding depth to the fresh top notes.
2D Molecular Structure
SMILES: CC(C)[C@]12CC[C@](C)(CC1)O2
Chemistry, Properties & Perfumer Guide
The Chemistry
1,4-Cineole is a monoterpene oxide with a bicyclic structure. While found in trace amounts in some essential oils, commercial production typically involves the acid-catalyzed cyclization of terpene alcohols. The 1,4- configuration gives it distinct olfactory properties compared to the more common 1,8-cineole, with reduced camphoraceous intensity.
Physical & Chemical Properties
| Boiling Point | 176-178 °C |
|---|---|
| Density | 0.926 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Freshness booster |
| Functional Fragrance | 1-3% | Up to 8% | Clean, medicinal character |
Classic Accords
Tip: Use to bridge citrus top notes with woody heart notes in masculine fragrances.
Alternatives & Comparisons
More camphoraceous intensity when a stronger medicinal character is desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions.
RIFM Assessment
Considered safe at current usage levels based on RIFM evaluation.
Sustainability
Synthetic production avoids pressure on natural resources. Manufacturing processes typically have low environmental impact compared to natural extraction methods.
Explore 1,4-Cineole
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References
- Bauer et al. (2001). Monoterpenes in Essential Oils. Phytochemistry. PMID XXXXX
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 470-67-7Physical Properties
| Molecular Weight | 154.25 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 2.5🔬 PubChem |
| Boiling Point | 65 °C🔬 EPA CompTox |
| Vapor Pressure | 1.932 mmHg @ 25°C📊 OPERA |
| Involatility Index | 0.1677💻 Calculated |
| log Kp (skin permeability) | -1.866💻 Calculated |
| SMILES | CC(C)C12CCC(O1)(CC2)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Top💻 Calculated |
| Volatility Class | Moderate💻 Calculated |
| Persistence Score | 0.5 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | camphoraceousfreshpine• leffingwell |
| Functional Groups | ether💻 RDKit |
| “Diffusive camphoraceous-fresh odor, more camphor-like, and not as sweet as Eucalyptol (see next monograph).”📖 Arctander | |
| 1,4-Cineole has a light and mild camphoraceous odor and a cool, mildly spicelike flavor.📖 Fenaroli | |
Flavor Notes (Arctander)
| “Cool, somewhat spicy-herbaceous taste.”📖 Arctander |
Sensory Thresholds
| Odor Detection Threshold | 1 ppm📖 van Gemert |
Regulatory Status
| IOFI Classification | Nature Identical📖 Fenaroli |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID3047396
Physical Properties
| Molecular Weight | 154.253 g/mol🔬 EPA CompTox |
| Density | 0.889 g/cm^3🔬 EPA CTX |
| Boiling Point | 173.5 °C🔬 EPA CTX |
| Melting Point | 1 °C🔬 EPA CTX |
| Flash Point | 50.616 °C📊 OPERA |
| Refractive Index | 1.491 Dimensionless📊 OPERA |
| Molar Volume | 157.874 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.97 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.05 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.05 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.43 Log10 unitless📊 OPERA |
| Water Solubility | 0.011 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole🔬 EPA CTX |
Transport Properties
| Vapor Pressure | 1.93 mmHg🔬 EPA CTX |
| Viscosity | 3.295 cP📊 OPERA |
| Surface Tension | 31.937 dyn/cm📊 OPERA |
| Thermal Conductivity | 111.519 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 9.23 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 45.703 cm^3/mol📊 OPERA |
| Polarizability | 18.118 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
