1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (Fixolid) (CAS 1506-02-01) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (Fixolid)

CAS 1506-02-01

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (Fixolid)?

Fixolid is a synthetic fragrance ingredient used as a fixative in perfumes and scented products. It helps anchor volatile top notes and extends fragrance longevity. This molecule matters because it creates a smooth, woody-amber background that enhances other ingredients without overpowering them.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ IFRA compliant at recommended levels
⚠ Potential skin sensitizer at high concentrations
CAS
1506-02-01
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (Fixolid) Smell Like?

Fixolid presents a complex woody-ambergris character with subtle musky undertones. Initially crisp with a faintly metallic edge, it evolves into a warm, velvety base reminiscent of sun-baked driftwood. The dry-down reveals a sophisticated skin-like quality that blends seamlessly with florals and spices. Unlike sharper amber materials, Fixolid maintains a rounded softness throughout evaporation, acting as an invisible scaffold that lifts brighter notes.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

Fixolid belongs to the tetralin subclass of aromatic compounds, featuring a partially hydrogenated naphthalene core with multiple methyl substitutions. Its synthesis typically involves Friedel-Crafts acylation of tetramethyltetralin precursors. The sterically crowded structure contributes to its exceptional tenacity, while the acetyl group provides balanced polarity for good blending properties.

Physical & Chemical Properties

AppearanceColorless to pale yellow viscous liquid
Boiling PointNot established
Density~1.0 g/cm³ (estimated)

Perfumer Guide

Note Position
Base
Volatility
Very low (>24 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Fixative base note
Home Care0.1-0.5%Up to 1%Longevity enhancer

Classic Accords

Tip: Use below 3% to avoid masking delicate top notes.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

For cleaner ambery effects with less woody character

2
Timberol CAS 28219-61-2

When a more pronounced cedar-like dryness is desired

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific restrictions under current IFRA standards (Amendment 49).

GHS Classification

H315 Skin irritation

RIFM Assessment

Not currently evaluated by RIFM. Limited toxicology data available.

Sustainability

As a synthetic material, Fixolid production avoids natural resource depletion. Its complex structure requires multi-step synthesis with moderate energy inputs. No known environmental persistence concerns at usage levels.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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