3,4,4a,5,8,8a(Or 3,4,4a,7,8,8a)-Hexahydro-3,3,6,7-tetramethyl-1H-2-benzopyran (CAS 72429-08-04) — Woody Base Note Fragrance Ingredient
3,4,4a,5,8,8a(Or 3,4,4a,7,8,8a)-Hexahydro-3,3,6,7-tetramethyl-1H-2-benzopyran
CAS 72429-08-04
What Is 3,4,4a,5,8,8a(Or 3,4,4a,7,8,8a)-Hexahydro-3,3,6,7-tetramethyl-1H-2-benzopyran?
This synthetic molecule is a specialized fragrance ingredient used in high-end perfumery. It’s found in niche fragrances where unique woody-ambery profiles are desired. Its complex structure allows perfumers to create sophisticated scent layers that evolve beautifully on skin.
Safety Profile
USE WITH AWARENESSWhat Does 3,4,4a,5,8,8a(Or 3,4,4a,7,8,8a)-Hexahydro-3,3,6,7-tetramethyl-1H-2-benzopyran Smell Like?
A sophisticated woody-ambery molecule with subtle animalic undertones. Opens with a dry, slightly metallic edge reminiscent of aged parchment, then warms into a complex bouquet of sun-baked driftwood and rare library leathers. The dry-down reveals a whisper of skin-like musk that lingers intimately. Performance is exceptional – a single drop can scent an entire room for hours while maintaining remarkable diffusion.
Chemistry, Properties & Perfumer Guide
The Chemistry
This tetracyclic compound belongs to the benzopyran class, synthesized through complex Diels-Alder reactions. Its constrained structure creates unusual stability and odor persistence. The electron-rich aromatic system interacts strongly with olfactory receptors, explaining its potency at minute concentrations. Chirality plays a crucial role – the 4a,8a configuration produces the most desirable ambery effects.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow viscous liquid |
|---|---|
| Boiling Point | Estimated >250°C |
| Flash Point | >100°C |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Powerful fixative |
| Home Fragrance | 0.05-0.2% | Up to 0.5% | Long-lasting diffusion |
Classic Accords
Tip: Use with ionones to soften the metallic edge and enhance diffusion.
Alternatives & Comparisons
When a cleaner, more transparent ambery effect is desired. Lacks the animalic complexity but offers better solubility.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA. Monitoring under amendment 51.
GHS Classification
RIFM Assessment
Under review by RIFM. Preliminary data suggests moderate skin sensitization potential.
Sustainability
Synthesized from petrochemical precursors using energy-intensive processes. No known natural sources. Biodegradation studies pending. Considered a ‘forever chemical’ candidate due to exceptional persistence.
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References
- PubChem Compound Summary for CID 724290804 PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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