1.alpha.,5.alpha.-Dihydroguaiol (CAS 3526-75-8) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

1.alpha.,5.alpha.-Dihydroguaiol

CAS 3526-75-8

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 1.alpha.,5.alpha.-Dihydroguaiol?

1.alpha.,5.alpha.-Dihydroguaiol is a synthetic fragrance ingredient used in niche perfumery to add woody, ambery nuances. It’s found in premium personal care products and fine fragrances. This molecule is valued for its ability to enhance natural wood notes while providing stability and longevity in fragrance compositions.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major safety concerns at typical usage levels
⚠ Limited toxicological data available
CAS
3526-75-8
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 1.alpha.,5.alpha.-Dihydroguaiol Smell Like?

1.alpha.,5.alpha.-Dihydroguaiol presents a refined woody character with subtle ambery undertones. Its scent profile unfolds with initial dry wood shavings, evolving into a smooth, slightly sweet heart reminiscent of aged cedarwood. The dry-down reveals a clean, persistent woody base with faint balsamic whispers, adding depth without overpowering. It behaves like a more elegant cousin of guaiacwood, with better blending properties and less harshness.

Scent Profile
Layer 2

2D Molecular Structure

5-Azulenemethanol, decahydro-.alpha.,.alpha.,3,8-tetramethyl-, (3S,3aS,5R,8S,8aS)-

SMILES: C[C@H]1CC[C@@H]2[C@H]1C[C@@H](CC[C@@H]2C)C(C)(C)O

Chemistry, Properties & Perfumer Guide

The Chemistry

1.alpha.,5.alpha.-Dihydroguaiol belongs to the sesquiterpenoid alcohol class, structurally related to guaiol. While not found abundantly in nature, it’s synthesized to provide consistent quality and properties. The synthesis typically involves hydrogenation of guaiol or related precursors, creating a more stable molecule with modified olfactory characteristics. Its stereochemistry (1.alpha.,5.alpha. configuration) significantly influences its scent profile and performance in formulations.

Physical & Chemical Properties

Perfumer Guide

Note Position
Base
Volatility
Low (8+ hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Woody base note enhancer
Personal Care0.5-1.5%Up to 2%Provides woody persistence

Classic Accords

Tip: Use to add dry wood character without the sharpness of guaiacwood derivatives.

Alternatives & Comparisons

1
Guaiol CAS 489-86-1

For a more pronounced woody character with slight green nuances, though less stable in formulations.

2
Ebanol CAS 107898-54-4

When a richer, more diffusive woody note is desired, though with different chemical structure.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

No specific RIFM assessment found for this compound.

Sustainability

As a synthetic ingredient, 1.alpha.,5.alpha.-Dihydroguaiol avoids pressure on natural resources. Its production can be optimized for minimal environmental impact through green chemistry principles. Being a pure compound, it requires no agricultural land and has consistent quality, reducing formulation waste.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Ingredient Data Sheet

    CAS 3526-75-8

    Physical Properties

    Molecular Weight224.38 g/mol🔬 PubChem
    LogP (Octanol-Water)4.4🔬 PubChem
    Boiling Point288 °C🔬 EPA CompTox
    Vapor Pressure0.0071 mmHg @ 25°C📊 OPERA
    Flash Point138.6 °C🔬 EPA CompTox
    Involatility Index0.0005💻 Calculated
    log Kp (skin permeability)-0.945💻 Calculated
    SMILESCC1CCC(CC2C1CCC2C)C(C)(C)O🔬 PubChem

    Volatility & Performance

    Fragrance NoteBase💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score4.9 / 5💻 Calculated

    Odor & Flavor

    Functional Groupsalcohol💻 RDKit
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID50883986

    Physical Properties

    Molecular Weight 224.388 g/mol🔬 EPA CompTox
    Density 0.92 g/cm^3📊 OPERA
    Boiling Point 288.534 °C📊 OPERA
    Melting Point 78.7 °C📊 OPERA
    Flash Point 130.018 °C📊 OPERA
    Refractive Index 1.471 Dimensionless📊 OPERA
    Molar Volume 245.655 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 4.241 Log10 unitless📊 OPERA
    LogD (pH 5.5) 4.241 Log10 unitless📊 OPERA
    LogD (pH 7.4) 4.241 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 9.24 Log10 unitless📊 OPERA
    Water Solubility 0.001 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.003 mmHg📊 OPERA
    Viscosity 24.733 cP📊 OPERA
    Surface Tension 30.889 dyn/cm📊 OPERA
    Thermal Conductivity 120.242 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 20.23 Ų💻 Computed
    H-Bond Donors 1 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 1 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 68.683 cm^3/mol📊 OPERA
    Polarizability 27.228 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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