1-Cyclohexene-1-propanal, 4-(1-methylethyl)-, (4R) (CAS 1378867-81-2) — Green Top to middle Note Fragrance Ingredient
1-_Cyclohexene-_1-_propanal, 4-_(1-_methylethyl)_-_, (4R)_
CAS 1378867-81-2
What Is 1-_Cyclohexene-_1-_propanal, 4-_(1-_methylethyl)_-_, (4R)_?
This is a synthetic fragrance ingredient used in modern perfumery to create fresh, green, and slightly woody accents. While not commonly recognized by name, it contributes to sophisticated scent profiles in contemporary fragrances. Its importance lies in its ability to bridge herbal and woody notes, adding complexity without overwhelming other ingredients. Perfumers value it for its versatility in both masculine and feminine compositions.
Safety Profile
GENERALLY SAFEWhat Does 1-_Cyclohexene-_1-_propanal, 4-_(1-_methylethyl)_-_, (4R)_ Smell Like?
This molecule presents a crisp, green opening reminiscent of crushed leaves and fresh sap, with subtle citrus undertones. As it evolves, a refined woody character emerges – not dense like sandalwood but more akin to freshly cut twigs with a faint resinous quality. The dry-down reveals a clean, almost metallic edge that provides excellent lift to fragrance compositions. It behaves like a chameleon, amplifying floral notes when paired with jasmine but taking on an earthy demeanor when combined with vetiver.
Chemistry, Properties & Perfumer Guide
The Chemistry
This cyclohexene derivative belongs to the class of unsaturated aldehydes, characterized by its isopropyl substitution at the 4-position. The (R)-enantiomer exhibits more favorable olfactory properties than its stereoisomer. Synthesized through selective hydrogenation of corresponding aromatic precursors followed by asymmetric oxidation, this molecule demonstrates how subtle structural modifications can significantly impact scent profiles. Its reactivity makes it useful as a building block for more complex fragrance molecules.
Physical & Chemical Properties
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Used as modifier rather than main note |
| Functional Fragrance | 0.1-0.5% | Up to 1% | Adds freshness to detergents |
Classic Accords
Tip: Stabilize in ethanol before adding to oil-based compositions to prevent aldehyde polymerization.
Alternatives & Comparisons
Offers similar green character but with more citrusy top notes and better stability in alkaline systems.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No current IFRA restrictions. Not listed in any amendments as of 2023.
RIFM Assessment
Under evaluation by RIFM. Preliminary data suggests low sensitization potential.
Sustainability
As a synthetic material, this ingredient doesn’t deplete natural resources but requires energy-intensive manufacturing. Future green chemistry approaches may improve its environmental profile. It offers advantages over some natural alternatives by avoiding agricultural land use and providing consistent quality.
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