1-Methylcyclododecyl methyl ether (CAS 37514-30-0) — Woody Base Note Fragrance Ingredient
1-Methylcyclododecyl methyl ether
CAS 37514-30-0
What Is 1-Methylcyclododecyl methyl ether?
1-Methylcyclododecyl methyl ether is a synthetic fragrance ingredient used in modern perfumery. It’s found in niche and designer fragrances seeking unique woody-musk effects. This compound matters because it offers perfumers a stable, long-lasting base note that can enhance depth and diffusion in complex formulations without being overly dominant.
Safety Profile
USE WITH AWARENESSWhat Does 1-Methylcyclododecyl methyl ether Smell Like?
1-Methylcyclododecyl methyl ether presents a subtle yet persistent olfactory profile. Initially, it reveals a crisp, almost ozonic freshness reminiscent of chilled mountain air. This quickly transitions into a heart of smooth, velvety woods – imagine sandalwood sanded to satin perfection. The dry-down is where it shines: a whisper-soft musk emerges, like clean skin after a shower, underpinned by an almost imperceptible mineralic quality. Throughout its evolution, it maintains remarkable quiet intensity – never shouting, but impossible to ignore once detected.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as the sole active ingredient to showcase its unique diffusive properties – creates an aura of clean, sophisticated musk that evolves subtly over hours.
Employed for its chameleon-like ability to adapt to skin chemistry, providing a transparent yet persistent base that amplifies other notes.
2D Molecular Structure
SMILES: COC1(C)CCCCCCCCCCC1
Chemistry, Properties & Perfumer Guide
The Chemistry
1-Methylcyclododecyl methyl ether belongs to the class of cyclic ethers, specifically a methyl-substituted cyclododecyl methyl ether. The molecule features a 12-membered carbon ring with a methoxy group at one position and a methyl group at another. Synthesis typically involves the methylation of cyclododecanol followed by selective oxidation. The large ring structure contributes to its excellent stability and slow evaporation rate, while the ether linkage provides subtle polarity that influences its diffusion properties.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Odor Threshold | Extremely low (high potency) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Used for subtle diffusion enhancement |
| Functional Fragrance | 0.5-1% | Up to 2% | Provides clean background note |
Classic Accords
Tip: Use as a transparent fixative to ‘lift’ other base notes without adding significant character.
Alternatives & Comparisons
When seeking more pronounced ambery-woody effects with similar diffusion properties.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA standards.
RIFM Assessment
Under review by RIFM as of 2023, preliminary data suggests low sensitization potential.
Sustainability
As a synthetic material, production can be carefully controlled to minimize environmental impact. No known issues with unsustainable sourcing since it’s not derived from natural materials. The manufacturing process can be optimized for energy efficiency given its synthetic nature.
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Physicochemical Properties
DTXSID: DTXSID4068034
Physical Properties
| Molecular Weight | 212.377 g/mol🔬 EPA CompTox |
| Density | 0.843 g/cm^3📊 OPERA |
| Boiling Point | 269.212 °C📊 OPERA |
| Melting Point | -15.004 °C📊 OPERA |
| Flash Point | 105.111 °C📊 OPERA |
| Refractive Index | 1.45 Dimensionless📊 OPERA |
| Molar Volume | 247.581 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.922 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 5.922 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.922 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.87 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0.001 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.013 mmHg📊 OPERA |
| Viscosity | 6.551 cP📊 OPERA |
| Surface Tension | 29.47 dyn/cm📊 OPERA |
| Thermal Conductivity | 132.987 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 9.23 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 66.574 cm^3/mol📊 OPERA |
| Polarizability | 26.392 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
