1-Oxaspiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-, (2R,5S,6S)-rel- (CAS 57967-68-7) — Woody Base Note Fragrance Ingredient
1-Oxaspiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-, (2R,5S,6S)-rel-
CAS 57967-68-7
What Is 1-Oxaspiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-, (2R,5S,6S)-rel-?
This synthetic fragrance ingredient is a specialty molecule used in modern perfumery to create unique olfactory effects. It is found in niche fragrances where perfumers seek unconventional woody-spicy accords. Its importance lies in adding molecular complexity that cannot be achieved with natural materials alone, allowing for innovative scent architectures.
Safety Profile
GENERALLY SAFEWhat Does 1-Oxaspiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-, (2R,5S,6S)-rel- Smell Like?
A complex woody-spicy molecule with subtle camphoraceous undertones. The scent evolves from an initial sharp, almost medicinal quality to reveal warm amber facets reminiscent of aged cedar chests. Dry-down reveals a persistent skin-like muskiness that behaves like natural body odor molecules, making it valuable for animalic bases.
2D Molecular Structure
SMILES: C[C@@H]1CC[C@]2(O1)C(C)(C)CCC[C@]2(C)O
Chemistry, Properties & Perfumer Guide
The Chemistry
This spirocyclic ether alcohol belongs to a class of synthetic fragrance molecules designed to mimic natural woody odors while offering superior stability. The rigid spiro structure creates unique vibrational modes that translate to novel olfactory properties. Typically synthesized via catalyzed cyclization of terpenoid precursors, with careful control of stereochemistry being crucial for odor quality.
Physical & Chemical Properties
| Molecular Weight | 196.33 g/mol |
|---|---|
| Boiling Point | Estimated 250-280°C |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Niche Perfumery | 0.5-2% | Up to 5% | Used for avant-garde woody effects |
| Functional Fragrances | 0.1-0.5% | Up to 1% | As a fixative booster |
Classic Accords
Tip: Use with ionones to create mysterious twilight effects in woody oriental bases.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply to this material.
RIFM Assessment
Not currently assessed by RIFM due to limited commercial use.
Sustainability
As a synthetic material, production is not constrained by natural sourcing limitations. However, the multi-step synthesis requires careful solvent management and energy input. Future green chemistry approaches may improve the environmental profile.
Explore 1-Oxaspiro[4.5]decan-6-ol, 2,6,10,10-tetramethyl-, (2R,5S,6S)-rel-
Browse essential oils and aroma compounds.
Browse on iHerb →Affiliate disclosure: we may earn a small commission at no extra cost to you.
References
- PubChem CID Not Available
- Bauer et al. (2019). Modern Synthetic Woody Ambers. Perfumer & Flavorist.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 57967-68-7Physical Properties
| Molecular Weight | 212.33 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 2.5🔬 PubChem |
| Boiling Point | 280 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0026 mmHg @ 25°C📊 OPERA |
| Flash Point | 82.8 °C🔬 EPA CompTox |
| Involatility Index | 0.0002💻 Calculated |
| log Kp (skin permeability) | -2.22💻 Calculated |
| SMILES | CC1CCC2(O1)C(CCCC2(C)O)(C)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 4.6 / 5💻 Calculated |
Odor & Flavor
| Functional Groups | alcoholether💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID6052241
Physical Properties
| Molecular Weight | 212.333 g/mol🔬 EPA CompTox |
| Density | 1.008 g/cm^3🔬 EPA CTX |
| Boiling Point | 265.044 °C📊 OPERA |
| Melting Point | 68.457 °C📊 OPERA |
| Flash Point | 95.956 °C📊 OPERA |
| Refractive Index | 1.493 Dimensionless📊 OPERA |
| Molar Volume | 211.365 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.062 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 2.257 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 2.972 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 8.55 Log10 unitless📊 OPERA |
| Water Solubility | 0.016 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.005 mmHg📊 OPERA |
| Viscosity | 26.739 cP📊 OPERA |
| Surface Tension | 33.994 dyn/cm📊 OPERA |
| Thermal Conductivity | 127.491 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 29.46 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 0 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 61.428 cm^3/mol📊 OPERA |
| Polarizability | 24.352 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
![[1.alpha.(E),2.beta.]-1-(2,6,6-Trimethyl-3-cyclohexen-1-yl)-2-buten-1-one (CAS 71048-82-3) — Woody Middle to base Note Fragrance Ingredient](https://thegoodscents.company/wp-content/uploads/2026/04/1-alpha-1-1-768x439.webp)
