1H-Indende-2-methanol, 2,3-dihydro-2,5-dimethyl- (CAS 285977-85-7) — Woody Heart to Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

1H-Indende-2-methanol, 2,3-dihydro-2,5-dimethyl-

CAS 285977-85-7

Origin
synthetic
Note
Heart to Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 1H-Indende-2-methanol, 2,3-dihydro-2,5-dimethyl-?

1H-Indende-2-methanol, 2,3-dihydro-2,5-dimethyl- is a synthetic fragrance ingredient used in modern perfumery. It contributes unique aromatic qualities to fragrances. This compound is valued for its ability to enhance depth and complexity in scent compositions, often found in niche and designer perfumes.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Limited safety data available
CAS
285977-85-7
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 1H-Indende-2-methanol, 2,3-dihydro-2,5-dimethyl- Smell Like?

This synthetic molecule offers a complex aromatic profile with woody and slightly floral undertones. It evolves from a fresh, slightly green top note to a warm, resinous heart, settling into a subtle balsamic base. Its dry-down is reminiscent of aged woods with a hint of spice, making it versatile in modern perfumery.

Scent Profile
Layer 2

2D Molecular Structure

1H-Indene-2-methanol, 2,3-dihydro-2,5-dimethyl-

SMILES: CC1=CC2=C(CC(C)(CO)C2)C=C1

Chemistry, Properties & Perfumer Guide

The Chemistry

1H-Indende-2-methanol, 2,3-dihydro-2,5-dimethyl- is a synthetic aromatic alcohol. It belongs to the indene class of compounds, known for their woody and balsamic characteristics. While its exact synthesis route is proprietary, it likely involves catalytic hydrogenation and methylation of indene precursors. Its structure suggests moderate stability and good blending potential in fragrance formulations.

Physical & Chemical Properties

Perfumer Guide

Note Position
Heart to Base
Volatility
Moderate (2-6 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-5%Up to 10%Adds woody depth
Home Fragrance0.5-3%Up to 5%Enhances longevity

Classic Accords

Tip: Use in small amounts to add woody complexity without overpowering other notes.

Alternatives & Comparisons

1
Indole CAS 120-72-9

Offers similar depth but with more floral characteristics. Useful when a jasmine-like note is desired.

2
Cedrol CAS 77-53-2

Provides a cleaner woody profile, ideal for fresh or citrus-dominated fragrances.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No current IFRA restrictions. Monitor for future updates as safety data evolves.

RIFM Assessment

No RIFM assessment available. Considered safe at current usage levels based on structural analogs.

Sustainability

As a synthetic molecule, this ingredient avoids natural resource depletion. Its production likely involves petrochemical precursors, with environmental impact dependent on manufacturing processes. Future green chemistry approaches may improve its sustainability profile.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Physicochemical Properties

    DTXSID: DTXSID5051367

    Physical Properties

    Molecular Weight 176.259 g/mol🔬 EPA CompTox
    Density 1.036 g/cm^3📊 OPERA
    Boiling Point 270.46 °C📊 OPERA
    Melting Point 66.223 °C📊 OPERA
    Flash Point 126.629 °C📊 OPERA
    Refractive Index 1.542 Dimensionless📊 OPERA
    Molar Volume 171.793 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 3.116 Log10 unitless📊 OPERA
    LogD (pH 5.5) 3.116 Log10 unitless📊 OPERA
    LogD (pH 7.4) 3.116 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 8.56 Log10 unitless📊 OPERA
    Water Solubility 0.003 mol/L📊 OPERA
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.006 mmHg📊 OPERA
    Viscosity 10.383 cP📊 OPERA
    Surface Tension 38.981 dyn/cm📊 OPERA
    Thermal Conductivity 132.891 mW/(m*K)📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 20.23 Ų💻 Computed
    H-Bond Donors 1 count💻 Computed
    H-Bond Acceptors 1 count💻 Computed
    Rotatable Bonds 1 count💻 Computed
    Aromatic Rings 1 count💻 Computed
    Molar Refractivity 54.094 cm^3/mol📊 OPERA
    Polarizability 21.445 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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