2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal (CAS 300371-33-9) — Woody Middle to base Note Fragrance Ingredient

Woody · Balsamic

2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal

CAS 300371-33-9

Origin
synthetic
Note
Middle to base
IFRA
Use with awareness
Data as of: Apr 2026

What Is 2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal?

2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal is a synthetic fragrance ingredient used in modern perfumery to add woody and amber nuances. It’s often found in masculine scents and woody-amber bases. This molecule contributes to long-lasting fragrance effects, particularly in designer colognes where warm dry-downs are desired.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
IFRA compliant at standard usage levels
Limited toxicological data available
CAS
300371-33-9
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal Smell Like?

This synthetic aldehyde opens with a crisp, slightly metallic edge reminiscent of fresh-cut aluminum foil, quickly warming into a complex woody-amber character. The dry-down reveals a sophisticated interplay between dry cedar shavings and the faint sweetness of aged cognac barrels, with a subtle animalic undertone that never dominates but provides depth. In dilution, it behaves like sun-warmed driftwood – retaining structural integrity while acquiring a polished smoothness.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

2,3-Dihydro-1,1-dimethyl-1H-indene-ar-propanal belongs to the class of indane derivatives, structurally featuring a fused aromatic and aliphatic system. The molecular architecture combines an indane core with a propanal sidechain, creating unique conformational constraints that influence its odor profile. Synthesis typically involves Friedel-Crafts alkylation followed by controlled oxidation to introduce the aldehyde functionality. The stereochemistry at the propanal position significantly impacts odor intensity, with the (R)-enantiomer displaying greater olfactory potency.

Physical & Chemical Properties

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-6 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-3%Up to 5%Base note modifier
Functional Fragrance0.1-1%Up to 2%Amber accord component

Classic Accords

Tip: Use with ionones to soften metallic top notes while maintaining projection.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

For cleaner ambery effects without metallic facets

2
Norlimbanol CAS 70788-30-6

When more pronounced woody dryness is required

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No current IFRA restrictions. Listed on IFRA Transparency List.

RIFM Assessment

Under evaluation by RIFM as of 2023.

Sustainability

As a synthetic material, this ingredient avoids natural resource depletion but requires petrochemical feedstocks. Manufacturing typically involves solvent-based processes requiring proper waste management. The molecular efficiency (high odor impact per gram) reduces environmental load compared to some natural alternatives.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 300371-33-9
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

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