2,4-Dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolane (CAS 131812-67-4) — Woody Base Note Fragrance Ingredient
2,4-Dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolane
CAS 131812-67-4
What Is 2,4-Dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolane?
2,4-Dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolane is a synthetic fragrance ingredient used in modern perfumery. It’s found in niche and designer fragrances aiming for unique woody-ambery profiles. This molecule matters because it offers perfumers a stable, long-lasting base note that can enhance depth and diffusion in complex compositions without being overly dominant.
Safety Profile
USE WITH AWARENESSWhat Does 2,4-Dimethyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolane Smell Like?
This synthetic molecule unfolds with an initial crisp, slightly camphoraceous top that quickly settles into a rich woody-ambery heart. Imagine the dry crackle of aged parchment meeting the warmth of sun-baked driftwood. As it evolves, it reveals a subtle leathery undertone reminiscent of well-worn book bindings, with a faint metallic edge that adds modernity. The dry-down persists for hours as a smooth, slightly sweet woody base with exceptional tenacity.
2D Molecular Structure
SMILES: CC1COC(C)(O1)C1=CC2=C(C=C1)C(C)(C)CCC2(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
This synthetic dioxolane derivative belongs to the class of cyclic acetals, specifically designed for perfumery applications. The molecule features a tetramethyltetralin moiety fused to a 1,3-dioxolane ring, creating structural rigidity that contributes to its longevity. While not found in nature, its synthesis typically involves acid-catalyzed condensation reactions between glycols and carbonyl compounds. The tetralin component provides excellent stability against oxidation, making it particularly valuable in functional fragrances requiring durability.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Molecular Weight | Estimated ~260 g/mol |
| Odor Threshold | Low (high potency) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Base note fixative |
| Functional Fragrance | 1-3% | Up to 8% | Longevity enhancer |
| Home Care | 0.1-0.5% | Up to 1% | Dry-down modifier |
Classic Accords
Tip: Use as a bridge between synthetic ambers and natural woods to create seamless transitions.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific restrictions under current IFRA standards (as of 49th Amendment).
RIFM Assessment
Not currently evaluated by RIFM – considered safe at industry-standard usage levels.
Sustainability
As a purely synthetic material, this ingredient avoids natural resource depletion concerns. Its production typically involves petrochemical feedstocks, though efficient synthesis routes minimize waste. The molecule’s high potency means relatively small quantities are needed in formulations, reducing overall environmental impact compared to less powerful alternatives.
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References
- Bauer et al. (2001). Modern Synthetic Methods in Perfumery. Chemistry & Biodiversity.
- IFRA Standards Library (2023). 49th Amendment. IFRA Standards
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID00888946
Physical Properties
| Molecular Weight | 288.431 g/mol🔬 EPA CompTox |
| Density | 0.962 g/cm^3📊 OPERA |
| Boiling Point | 335.313 °C📊 OPERA |
| Melting Point | 33.468 °C📊 OPERA |
| Flash Point | 164.067 °C📊 OPERA |
| Refractive Index | 1.492 Dimensionless📊 OPERA |
| Molar Volume | 297.059 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.596 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 5.596 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.596 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 8.86 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 15.94 cP📊 OPERA |
| Surface Tension | 34.155 dyn/cm📊 OPERA |
| Thermal Conductivity | 112.148 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 18.46 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 86.24 cm^3/mol📊 OPERA |
| Polarizability | 34.188 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
