Isocamphenyl cyclohexanol, mixed isomers (CAS 66068-84-6) — Woody Base Note Fragrance Ingredient
Isocamphenyl cyclohexanol, mixed isomers
CAS 66068-84-6
What Is Isocamphenyl cyclohexanol, mixed isomers?
Isocamphenyl cyclohexanol is a synthetic fragrance ingredient used in modern perfumery to create woody, ambery scents. You’ll encounter it in masculine colognes and home fragrance products. This molecule matters because it helps perfumers build long-lasting woody bases without using restricted natural materials like sandalwood.
Safety Profile
GENERALLY SAFEWhat Does Isocamphenyl cyclohexanol, mixed isomers Smell Like?
Isocamphenyl cyclohexanol unfolds with an initial woody-camphoraceous punch reminiscent of freshly split cedar planks, evolving into a smooth ambered heart with hints of dry tobacco leaf. The dry-down reveals exceptional tenacity, leaving a refined woody-musky trail that behaves like a synthetic sandalwood alternative. Its odor profile sits between Iso E Super’s transparency and Ambroxan’s animalic depth.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as 12% of the base accord to create a sustainable sandalwood alternative, blending with Cashmeran for velvety diffusion.
Forms 8% of the woody core, paired with Norlimbanol for enhanced projection in this masculine woody fragrance.
Chemistry, Properties & Perfumer Guide
The Chemistry
Isocamphenyl cyclohexanol belongs to the bicyclic tertiary alcohol class, synthesized through acid-catalyzed cyclization of camphene derivatives. The mixed isomers (primarily exo and endo forms) create a complex odor profile. Its synthesis typically involves Diels-Alder reactions followed by hydrogenation, yielding a stable molecule resistant to oxidation. The cyclohexanol moiety contributes to its substantivity on skin.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow viscous liquid |
|---|---|
| Odor Threshold | 0.01 ppm |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 5-12% | Up to 15% | Woody base builder |
| Functional Fragrance | 1-3% | Up to 5% | Fabric conditioner base |
Classic Accords
Tip: Use above 5% concentration to maximize its tenacity in woody-amber bases.
Alternatives & Comparisons
More transparent woody effect but lacks the amber richness of isocamphenyl cyclohexanol.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions under Amendment 49
GHS Classification
RIFM Assessment
Under evaluation for chronic exposure scenarios (2023).
Sustainability
Synthetic production avoids deforestation pressures associated with natural sandalwood. Manufactured through green chemistry principles with >85% atom economy.
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References
- IFRA Standards Library (2023). Amendment 49. IFRA 2023
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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