2,4-Dimethyl-4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxin (CAS 27606-09-03) — Woody Middle to base Note Fragrance Ingredient

Woody · Balsamic

2,4-Dimethyl-4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxin

CAS 27606-09-03

Origin
synthetic
Note
Middle to base
IFRA
Professional use
Data as of: Apr 2026

What Is 2,4-Dimethyl-4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxin?

2,4-Dimethyl-4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxin is a synthetic fragrance ingredient used in modern perfumery to add unique woody-ambery nuances. It’s found in select niche fragrances where innovative accords are desired. This compound helps perfumers create contemporary scent profiles that bridge traditional and avant-garde styles, offering a subtle complexity that enhances depth without overwhelming other notes.

Safety Profile

PROFESSIONAL USE
Generally safeUse with awarenessProfessional use
Limited safety data available
Professional handling recommended
CAS
27606-09-03
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 2,4-Dimethyl-4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxin Smell Like?

This synthetic molecule presents a sophisticated interplay of woody and ambery facets with a subtle metallic edge. Initially crisp and slightly camphoraceous, it evolves into a warm, textured base reminiscent of aged oak barrels with a whisper of leather. The dry-down reveals a lingering mineralic quality that provides excellent tenacity in complex compositions.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

2,4-Dimethyl-4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxin belongs to the class of heterocyclic oxygen compounds with a fused indene-dioxane structure. Its synthesis typically involves [4+2] cycloaddition reactions of appropriate diene precursors with carbonyl compounds. The rigid bicyclic framework contributes to its stability and distinctive odor profile.

Physical & Chemical Properties

AppearanceClear to pale yellow liquid
Molecular WeightNot specified

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-6 hours)
Blending
Specialized
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Used as a nuance enhancer
Functional Fragrance0.1-0.5%Up to 1%Limited use due to intensity

Classic Accords

Tip: Use sparingly in woody-amber bases to add structural depth without dominating the composition.

Alternatives & Comparisons

1
Ambroxan CAS 6790-58-5

Offers similar ambery depth with better-known safety profile and more predictable performance in formulations.

2
Iso E Super CAS 54464-57-2

Provides comparable woody diffusion with greater formulation flexibility and wider usage limits.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA. Professional assessment recommended due to limited safety data.

RIFM Assessment

No published RIFM assessment currently available for this compound.

Sustainability

As a synthetic material, this compound is produced through controlled chemical processes with minimal environmental impact compared to natural extraction methods. The manufacturing process can be optimized for atom economy, though specific life cycle assessment data is not publicly available for this niche material.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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