2-Hexyl-(E)-cinnamaldehyde (CAS 165184-98-5) — Sweet Middle Note Fragrance Ingredient
2-Hexyl-(E)-cinnamaldehyde
CAS 165184-98-5
What Is 2-Hexyl-(E)-cinnamaldehyde?
2-Hexyl-(E)-cinnamaldehyde is a synthetic fragrance ingredient that mimics the warm, spicy-sweet aroma of cinnamon. It is commonly found in perfumes, candles, and body care products. This ingredient adds depth and longevity to fragrances, making it valuable for creating rich, oriental scent profiles. Its synthetic nature ensures consistency and availability year-round.
Safety Profile
GENERALLY SAFEWhat Does 2-Hexyl-(E)-cinnamaldehyde Smell Like?
2-Hexyl-(E)-cinnamaldehyde offers a warm, spicy-sweet aroma reminiscent of cinnamon sticks with a hint of floral undertones. Initially, it presents a sharp, aldehydic top note that quickly mellows into a heart of rich, woody sweetness. Over time, it evolves into a deep, balsamic base that lingers on the skin. The scent is evocative of autumnal spices and exotic markets, with a complexity that adds sophistication to any blend.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
2D Molecular Structure
SMILES: CCCCCC\C(C=O)=C/C1=CC=CC=C1
Chemistry, Properties & Perfumer Guide
The Chemistry
2-Hexyl-(E)-cinnamaldehyde is a synthetic aldehyde with a molecular structure that combines a hexyl chain with a cinnamaldehyde backbone. It is typically synthesized via the aldol condensation of heptanal and benzaldehyde. The (E)-configuration ensures optimal olfactory properties. This compound is prized for its stability and consistent performance in formulations.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Adds warmth and spice |
| Candles | 2-8% | Up to 15% | Enhances longevity and richness |
Classic Accords
Tip: Use in small amounts to avoid overpowering other notes.
Alternatives & Comparisons
A simpler aldehyde with a stronger cinnamon aroma, used when a more pronounced spice note is desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under IFRA standards.
EU Allergen Declaration
Not listed as an EU allergen.
RIFM Assessment
RIFM has assessed this ingredient as safe for use in current practices.
Sustainability
As a synthetic ingredient, 2-Hexyl-(E)-cinnamaldehyde is not dependent on natural resources, making it a sustainable choice. Its production can be optimized to minimize environmental impact.
Explore 2-Hexyl-(E)-cinnamaldehyde
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References
- PubChem. 2-Hexyl-(E)-cinnamaldehyde. PubChem
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 165184-98-5Physical Properties
| Molecular Weight | 216.32 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 4.8🔬 PubChem |
| Boiling Point | 310.8 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0005 mmHg @ 25°C📊 OPERA |
| Flash Point | 151 °C🔬 EPA CompTox |
| log Kp (skin permeability) | -0.612💻 Calculated |
| SMILES | CCCCCCC(=CC1=CC=CC=C1)C=O🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 7.8 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | spicysweet• leffingwell |
| Functional Groups | aldehydealkenearomatic💻 RDKit |
| “Very mild, sweet-oily, slightly floral odor H.C.A. The odor becomes considerably more floral and lively when the material is incorporated with more volatile material in a composition. pleasant oily-hcrbaccous odor-contribution to B.P. and in general as part of a floral theme in other fragrance types. There are many per- octenal ‘“contribute unpleasant, fatty, rancid fumers who find this aldehyde s”📖 Arctander | |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID401020801
Physical Properties
| Molecular Weight | 216.324 g/mol🔬 EPA CompTox |
| Density | 0.95 g/cm^3🔬 EPA CTX |
| Boiling Point | 310.8 °C🔬 EPA CTX |
| Melting Point | 17.6 °C🔬 EPA CTX |
| Flash Point | 151 °C🔬 EPA CTX |
| Refractive Index | 1.53 Dimensionless📊 OPERA |
| Molar Volume | 226.569 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.3 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 4.612 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 4.612 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.38 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.001 mmHg🔬 EPA CTX |
| Viscosity | 5.94 cP📊 OPERA |
| Surface Tension | 35.789 dyn/cm📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 7 count💻 Computed |
| Aromatic Rings | 1 count💻 Computed |
| Molar Refractivity | 69.969 cm^3/mol📊 OPERA |
| Polarizability | 27.738 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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