2-Isopropylphenol (CAS 88-69-7) — Woody Middle Note Fragrance Ingredient
2-Isopropylphenol
CAS 88-69-7
What Is 2-Isopropylphenol?
2-Isopropylphenol is a synthetic aromatic compound used in fragrances and industrial applications. Consumers may encounter it as a subtle component in perfumes, soaps, or cleaning products where it contributes to complex scent profiles. This ingredient matters because it helps create depth and longevity in fragrance formulations, acting as a versatile building block for perfumers to craft unique olfactory experiences.
Safety Profile
USE WITH AWARENESSWhat Does 2-Isopropylphenol Smell Like?
2-Isopropylphenol presents a sharp, phenolic aroma with medicinal undertones reminiscent of disinfectants or tar. The scent evolves from an initial aggressive, almost rubber-like top note to a warmer, slightly smoky heart. In dry-down, it leaves a persistent woody-balsamic trace that blends well with other aromatics. The odor profile suggests comparisons to creosote or aged whiskey barrels, offering perfumers a tool for creating rugged, masculine accords or adding phenolic complexity to leather and tobacco compositions.
Chemistry, Properties & Perfumer Guide
The Chemistry
2-Isopropylphenol belongs to the alkylphenol class of aromatic compounds. As a synthetic material, it’s produced through Friedel-Crafts alkylation of phenol with propylene. The isopropyl group at the ortho position creates steric hindrance that influences both its chemical reactivity and odor profile. Unlike some phenolic compounds, it lacks significant chirality due to its simple symmetric substitution pattern. Its molecular structure contributes to moderate volatility and good blending properties with both polar and non-polar fragrance ingredients.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Used for phenolic accents |
| Functional Fragrance | 0.1-1% | Up to 3% | Disinfectant-type profiles |
Classic Accords
Tip: Use sparingly in blends to add phenolic complexity without overwhelming other notes.
Alternatives & Comparisons
Less harsh para-isomer with similar phenolic character but smoother profile.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific IFRA restrictions currently apply to 2-isopropylphenol.
GHS Classification
RIFM Assessment
RIFM has not published a specific safety assessment for this material.
Sustainability
As a synthetic material, 2-isopropylphenol’s environmental impact comes primarily from petrochemical feedstocks and manufacturing energy use. Unlike some natural phenols, it doesn’t contribute to deforestation or agricultural land use issues. Proper handling during production and disposal is necessary to prevent environmental release of phenolic compounds.
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