3-Dodecyldihydrofuran-2(3H)-one (CAS 73263-36-2) — Musky Base Note Fragrance Ingredient
3-Dodecyldihydrofuran-2(3H)-one
CAS 73263-36-2
What Is 3-Dodecyldihydrofuran-2(3H)-one?
3-Dodecyldihydrofuran-2(3H)-one is a synthetic fragrance ingredient primarily used in perfumery to add subtle musky and fruity nuances. You won’t encounter it directly, but it may be part of the complex scent profiles in fine fragrances or personal care products. This molecule matters because it helps perfumers create long-lasting, sophisticated accords, particularly in modern floral and woody compositions where a clean musk effect is desired.
Safety Profile
USE WITH AWARENESSWhat Does 3-Dodecyldihydrofuran-2(3H)-one Smell Like?
This synthetic musk presents as a clean, intimate scent with surprising complexity. Initially, it offers a faintly fruity character reminiscent of peach skin or overripe apricot, quickly transitioning to a soft musky heart with hints of freshly laundered cotton. The dry-down reveals a subtle woody undertone, behaving like a quiet harmonic that amplifies surrounding florals without announcing itself. Its tenacity is remarkable for such a lightweight molecule, clinging to skin for hours as a barely-there veil of sophistication.
2D Molecular Structure
SMILES: CCCCCCCCCCCCC1CCOC1=O
Chemistry, Properties & Perfumer Guide
The Chemistry
As a synthetic furanone derivative, 3-Dodecyldihydrofuran-2(3H)-one belongs to the class of cyclic esters with a long alkyl chain. Its structure combines the lactone functionality of furanones with the hydrophobic character of dodecyl groups, explaining its dual fruity-musky odor profile. Industrial synthesis typically involves ring-closing reactions of appropriate hydroxy acids or oxidation of corresponding furans. The molecule’s conformational flexibility allows it to interact with multiple olfactory receptors, creating its nuanced scent character.
Physical & Chemical Properties
| Molecular Class | Furanone derivative |
|---|---|
| Odor Type | Musky-fruity |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Used as musky enhancer |
| Personal Care | 0.1-0.5% | Up to 1% | Skin-sensory modifier |
Classic Accords
Tip: Use below 3% to avoid masking delicate top notes while maintaining musky persistence.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific IFRA restrictions currently apply to this material (as of Amendment 51).
RIFM Assessment
Under evaluation by RIFM; preliminary data suggests low sensitization potential.
Sustainability
As a purely synthetic material, 3-Dodecyldihydrofuran-2(3H)-one doesn’t rely on agricultural resources. Its production typically involves petrochemical feedstocks, though modern green chemistry approaches may offer more sustainable synthesis routes. The molecule’s potency means only small quantities are needed, reducing overall environmental load compared to less powerful musks.
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References
- IFRA Standards Library (2023). Amendment 51. IFRA
- Brenna, E. et al. (2012). Synthetic Musks in Perfumery. Chemistry & Biodiversity. DOI:10.1002/cbdv.201100323
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID50868238
Physical Properties
| Molecular Weight | 254.414 g/mol🔬 EPA CompTox |
| Density | 0.905 g/cm^3📊 OPERA |
| Boiling Point | 336.895 °C📊 OPERA |
| Melting Point | 24.574 °C📊 OPERA |
| Flash Point | 146.601 °C📊 OPERA |
| Refractive Index | 1.456 Dimensionless📊 OPERA |
| Molar Volume | 278.896 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.962 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 5.962 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.962 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 8.95 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 7.202 cP📊 OPERA |
| Surface Tension | 32.303 dyn/cm📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 26.3 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 11 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 75.838 cm^3/mol📊 OPERA |
| Polarizability | 30.065 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
