Ethylene Brassylate (CAS 105-95-3) — Sweet Base Note Fragrance Ingredient
Ethylene Brassylate
CAS 105-95-3
What Is Ethylene Brassylate?
Ethylene Brassylate is a synthetic musk widely used in perfumery for its soft, powdery, and sweet scent. It’s found in laundry detergents, fabric softeners, and personal care products like lotions and deodorants. This ingredient is prized for its long-lasting fragrance and ability to enhance other notes, making it a staple in modern perfumery.
Safety Profile
GENERALLY SAFE
What Does Ethylene Brassylate Smell Like?
Ethylene Brassylate offers a smooth, velvety musk with powdery undertones, reminiscent of freshly laundered linen. It evolves from a slightly sweet, floral opening to a warm, skin-like dry-down. Its subtlety makes it a versatile base note, blending seamlessly with florals, woods, and spices.
Scent Profile
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the floral bouquet and add a soft, powdery muskiness that balances the aldehydes and florals.
Provides a long-lasting, sweet musk base that complements the patchouli and vanilla notes.
2D Molecular Structure
SMILES: O=C1CCCCCCCCCCCC(=O)OCCO1
Chemistry, Properties & Perfumer Guide
The Chemistry
Ethylene Brassylate is a macrocyclic musk ester, synthesized through esterification of brassilic acid with ethylene glycol. It belongs to the class of polycyclic musks, known for their stability and low volatility. Its synthetic origin ensures consistency and sustainability compared to natural musk alternatives.
Physical & Chemical Properties
| Boiling Point | N/A |
|---|---|
| Density | N/A |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 5-15% | Up to 20% | Adds longevity and softness |
| Personal Care | 1-5% | Up to 10% | Provides a subtle, clean scent |
Classic Accords
+ Rose + Patchouli = Romantic Floral
Tip: Use in conjunction with other musks to create depth and longevity.
Alternatives & Comparisons
A stronger, more diffusive musk often used when a more pronounced effect is desired.
A lighter, more transparent musk suitable for fresh and clean fragrances.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. IFRA, REACH, EU Cosmetics Regulation standards update periodically. Consult current IFRA Standards Library before formulating. Not legal or regulatory advice.
IFRA Status
Not restricted by IFRA.
RIFM Assessment
RIFM considers Ethylene Brassylate safe for use in current applications.
Sustainability
As a synthetic ingredient, Ethylene Brassylate avoids the ethical and environmental concerns associated with natural musk. Its production is scalable and consistent, reducing reliance on animal-derived materials.
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Industry & Science Data
References
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Mar 2026.
Ingredient Data Sheet
CAS 105-95-3Physical Properties
| Molecular Weight | 270.36 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 4.2🔬 PubChem |
| Boiling Point | 138 °C🔬 EPA CompTox |
| Flash Point | 161 °C🔬 EPA CompTox |
| log Kp (skin permeability) | -1.367💻 Calculated |
| SMILES | C1CCCCCC(=O)OCCOC(=O)CCCCC1🔬 PubChem |
Volatility & Performance
| Fragrance Note | Top💻 Calculated |
Odor & Flavor
| Primary Descriptors | fattymuskysweet• leffingwell |
| Functional Groups | esterether💻 RDKit |
| “Sweet-musky, somewhat oily odor of outstanding tenacity.”📖 Arctander | |
| Ethyl brassylate has musk-like character and sweet odor.📖 Fenaroli | |
Flavor Notes (Arctander)
| “The use of this material in flavor compositions as a fixative and "rounding-off" agent has been suggested.”📖 Arctander |
Sensory Thresholds
| Odor Detection Threshold | 0.0467 ppm (n=2)📖 van Gemert |
Regulatory Status
| IOFI Classification | Artificial📖 Fenaroli |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID1044774
Physical Properties
| Molecular Weight | 270.369 g/mol🔬 EPA CompTox |
| Density | 1.04 g/cm^3🔬 EPA CTX |
| Boiling Point | 353.1 °C🔬 EPA CTX |
| Melting Point | 87.833 °C🔬 EPA CTX |
| Flash Point | 161 °C🔬 EPA CTX |
| Refractive Index | 1.438 Dimensionless📊 OPERA |
| Molar Volume | 276.656 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 4.3 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.615 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.615 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 9.27 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 6.047 cP📊 OPERA |
| Surface Tension | 30.92 dyn/cm📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 52.6 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 4 count💻 Computed |
| Rotatable Bonds | 0 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 72.648 cm^3/mol📊 OPERA |
| Polarizability | 28.8 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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