3-Mercapto-2-pentanone (CAS 67633-97-0) — Balsamic Heart Note Fragrance Ingredient

Balsamic · Sweet

3-Mercapto-2-pentanone

CAS 67633-97-0

Origin
synthetic
Note
Heart
IFRA
Use with awareness
Data as of: Apr 2026

What Is 3-Mercapto-2-pentanone?

3-Mercapto-2-pentanone is a synthetic fragrance ingredient used to add meaty, savory nuances to perfumes and flavorings. It’s found in some gourmand and savory-leaning fragrances. This molecule matters because it can create unique umami effects when blended with fruity or floral notes, offering perfumers a tool for unconventional compositions.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
Requires careful handling
Strong odor impact
CAS
67633-97-0
Formula
Mixture
MW
Variable
Odor Family
Balsamic · Sweet
Layer 1 · Enthusiast

What Does 3-Mercapto-2-pentanone Smell Like?

3-Mercapto-2-pentanone delivers a potent, savory-meaty character reminiscent of roasted meats or fried onions at full strength. When diluted, it reveals a complex interplay of sulfurous depth with fruity undertones. The top note is intensely sulfuraceous, evolving into a heart that balances meaty richness with a subtle tropical fruitiness. The dry-down leaves a lingering savory impression that works exceptionally well in gourmand accords.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

3-Mercapto-2-pentanone belongs to the class of sulfur-containing ketones, specifically a pentanone with a mercapto group at the 3-position. It’s exclusively synthetic, typically produced through the reaction of 2-pentanone with hydrogen sulfide or via organosulfur chemistry routes. The sulfur atom contributes significantly to its odor profile, creating strong meaty-sulfuraceous notes even at low concentrations.

Physical & Chemical Properties

Perfumer Guide

Note Position
Heart
Volatility
Medium (2-4 hours)
Blending
Specialist
ApplicationTypical %RangeNotes
Fine Fragrance0.01-0.1%Up to 0.5%Used sparingly for savory effects
Flavorings0.001-0.01%Up to 0.05%Meat flavor enhancer

Classic Accords

Tip: Use in trace amounts (ppm levels) for meaty nuances in gourmand compositions.

Alternatives & Comparisons

1
2-Methyl-3-furanthiol CAS 28588-74-1

More intense meaty character, used when stronger savory impact is desired.

2
Methional CAS 3268-49-3

Softer potato-like sulfur note, suitable for milder savory effects.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions. General sulfur compound handling guidelines apply.

GHS Classification

H315 Skin irritation H319 Eye irritation H335 May cause respiratory irritation

RIFM Assessment

Limited RIFM assessment data available. Considered safe at current usage levels.

Sustainability

As a synthetic material, 3-Mercapto-2-pentanone’s environmental impact depends on production methods. Being highly potent, it requires minimal quantities in formulations, reducing overall material consumption. No known natural sources exist, making synthetic production the only viable route.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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