5- and 6-Decenoic acid (CAS 72881-27-7) — Sweet Heart to base Note Fragrance Ingredient
5- and 6-Decenoic acid
CAS 72881-27-7
What Is 5- and 6-Decenoic acid?
5- and 6-Decenoic acid is a synthetic fragrance ingredient with a distinctive fatty, waxy character. It’s primarily used in perfumery to create creamy, milky, or slightly cheesy nuances. This ingredient matters because it adds unique lactonic and dairy-like facets to fragrances, helping perfumers replicate complex natural aromas that would otherwise be difficult to achieve.
Safety Profile
USE WITH AWARENESSWhat Does 5- and 6-Decenoic acid Smell Like?
5- and 6-Decenoic acid presents a complex olfactory profile that evolves from sharp, acidic top notes to a creamy, dairy-like heart. The initial impression is reminiscent of aged cheese or sour milk, which soon softens into a waxy, coconut-like aroma. In the dry-down, it reveals subtle animalic undertones that blend beautifully with floral and woody bases. The overall effect is like the transition from fresh goat cheese to sun-warmed coconut flesh, making it invaluable for creating rich, lactonic accords.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to create the photorealistic milk note, contributing creamy-lactonic depth that makes this fragrance so distinctive.
Provides the subtle coconut-milk nuance that softens the citrus-rice accord, adding creamy sophistication.
Chemistry, Properties & Perfumer Guide
The Chemistry
5- and 6-Decenoic acid belongs to the class of medium-chain fatty acids with unsaturated carbon chains. While not found in significant quantities in nature, it’s synthesized through controlled oxidation of decene or via specialized fermentation processes. The mixture typically contains both positional isomers (5- and 6-), with the 5-isomer being slightly more potent olfactively. The double bond position significantly influences the odor character, with 5-decenic acid being more lactonic while 6-decenic acid shows more fatty-waxy characteristics.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Odor Threshold | Very low (parts per million) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Used sparingly for dairy nuances |
| Functional Fragrances | 0.01-0.1% | Up to 0.3% | For creamy body care products |
Classic Accords
Tip: Use in trace amounts with lactones to enhance creamy effects without overpowering.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA. Approved for use within standard fragrance guidelines.
EU Allergen Declaration
Not listed as an EU allergen.
GHS Classification
RIFM Assessment
RIFM has reviewed this material and found it safe for use at current industry levels.
Sustainability
As a synthetic material, 5- and 6-Decenoic acid doesn’t rely on agricultural resources. Modern synthesis methods aim to minimize environmental impact through efficient catalysis and reduced solvent use. The carbon footprint is comparable to other specialty fragrance chemicals, with ongoing research into bio-based production routes.
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References
- Brenna et al. (2002). Lactones in Flavors and Fragrances. Chemistry & Biodiversity. DOI:10.1002/cbdv.200790001
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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