Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl)) (CAS 25322-69-4) — Citrus Non-fragrant Note Fragrance Ingredient

ByThe Good Scents
Citrus · Floral

Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl))

CAS 25322-69-4

Origin
synthetic
Note
Non-fragrant
IFRA
Generally safe
Data as of: Apr 2026

What Is Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl))?

Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl)) is a synthetic polymer used primarily as a solvent or carrier in industrial and cosmetic applications. Consumers may encounter it in products like lotions, creams, and certain cleaning agents where it helps stabilize formulations. While not a fragrance ingredient itself, this compound plays a supporting role in product performance by improving texture and delivery of active ingredients.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Approved for cosmetic use
⚠ Monitor for skin compatibility
CAS
25322-69-4
Formula
Mixture
MW
Variable
Odor Family
Citrus · Floral
Layer 1 · Enthusiast

What Does Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl)) Smell Like?

This synthetic polymer is essentially odorless, functioning primarily as a carrier rather than a fragrant material. Its neutral olfactory profile makes it valuable for formulations requiring minimal interference with delicate fragrance compositions.

Layer 2

2D Molecular Structure

Polypropylene glycol

SMILES: [H]OCCO[H].C* |lp:1:2,4:2,m:7:3.2,Sg:n:3,2,1,6,7::ht|

Chemistry, Properties & Perfumer Guide

The Chemistry

Alpha-hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl)) is a polyethylene glycol derivative synthesized through polymerization of ethylene oxide. The terminal hydroxyl groups allow for further chemical modifications. As a synthetic polymer, it lacks chirality and exists as an amorphous material with variable molecular weights depending on the degree of polymerization.

Physical & Chemical Properties

Perfumer Guide

Note Position
Non-fragrant
Volatility
Non-volatile
Blending
N/A
ApplicationTypical %RangeNotes
Cosmetic Formulations1-5%Up to 10%Solvent/carrier function
Cleaning Products2-8%Up to 15%Stabilizing agent

Classic Accords

Tip: Use as a neutral base for fragrance delivery systems requiring minimal olfactory interference.

Alternatives & Comparisons

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not restricted by IFRA as it is not a fragrance material.

RIFM Assessment

Not evaluated by RIFM as it is not a fragrance ingredient.

Sustainability

As a synthetic polymer, this material is produced through petrochemical processes. While not biodegradable, its use at relatively low concentrations in formulations minimizes environmental impact. Manufacturers are exploring bio-based alternatives to similar polyether compounds.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 25322-69-4
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID9027863

    Partition & Solubility

    LogP (Octanol-Water) -0.445 dimensionless💻 Computed

    Molecular Descriptors

    Topological Polar Surface Area 40.46 Ų💻 Computed
    H-Bond Donors 2 count💻 Computed
    H-Bond Acceptors 2 count💻 Computed
    Rotatable Bonds 1 count💻 Computed
    Aromatic Rings 0 count💻 Computed

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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