Benzene, 1-(dimethoxymethyl)-4-methoxy- (CAS 2186-92-7) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

Benzene, 1-_(dimethoxymethyl)_-_4-_methoxy-

CAS 2186-92-7

Origin
synthetic
Note
Middle
IFRA
Use with awareness
Data as of: Apr 2026

What Is Benzene, 1-_(dimethoxymethyl)_-_4-_methoxy-?

This synthetic fragrance ingredient is a specialized aromatic compound primarily used in high-end perfumery and industrial applications. Consumers may encounter it in niche fragrances where it contributes unique woody-anisic nuances. While not widely known by name, it plays a subtle role in creating complex accords, particularly in oriental and fougère compositions where its dry, herbaceous character adds depth.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
⚠ Limited safety data available
⚠ Potential sensitizer – use caution
CAS
2186-92-7
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does Benzene, 1-_(dimethoxymethyl)_-_4-_methoxy- Smell Like?

Presents an intriguing duality – opening with crisp, almost metallic anisic top notes that gradually reveal a warmer, woody-balsamic heart. The dry-down carries faint echoes of dried herbs and antique furniture polish, with a lingering sweetness reminiscent of aged parchment. Its tenacity is moderate, acting as a bridge between fleeting top notes and deeper base materials, though it never dominates a composition.

Scent Profile
Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

A methoxy-substituted benzene derivative belonging to the aromatic ethers class. Synthesized through Williamson ether synthesis or via methoxylation of phenolic precursors. The dimethoxymethyl group introduces steric hindrance that affects both volatility and odor characteristics. No chiral centers present in this symmetrical molecule, though positional isomers could theoretically exist.

Physical & Chemical Properties

AppearanceColorless to pale yellow liquid
Boiling PointEstimated 220-240 °C
DensityApprox. 1.05 g/cm³
SolubilitySoluble in ethanol, insoluble in water

Perfumer Guide

Note Position
Middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Background modifier
Functional Fragrance0.1-0.5%Up to 1%Trace use only
Household ProductsNot recommendedN/ALimited application

Classic Accords

Tip: Use with polar solvents to prevent separation in alcoholic compositions.

Alternatives & Comparisons

1
Methyl Diantilis CAS 13128-00-4

For similar anisic-woody effects with better safety profile

2
Veratraldehyde CAS 120-14-9

When more pronounced vanilla-like character is desired

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards, but usage should follow general aromatic compound guidelines.

GHS Classification

H315 Skin irritation H319 Eye irritation

RIFM Assessment

No specific RIFM evaluation available; treat as potential sensitizer based on structural analogs.

Sustainability

Synthesized from petrochemical precursors with moderate energy requirements. Not biodegradable; should be handled to prevent environmental release. No known natural occurrence limits renewable sourcing options. Future development could explore greener synthetic routes or bio-based alternatives.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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