Cyclamen Aldehyde (CAS 103-95-7) — Floral Heart Note Fragrance Ingredient




Cyclamen Aldehyde

CAS 103-95-7

Origin
Note
IFRA
Use with awareness
Data as of: Mar 2026

What Is Cyclamen Aldehyde?

Cyclamen Aldehyde is a synthetic fragrance ingredient commonly found in floral perfumes, soaps, and household products. It contributes a fresh, green floralcy reminiscent of lily-of-the-valley and cyclamen flowers. This versatile molecule helps create modern floral bouquets while adding diffusion and lift to fragrance compositions.

Safety Profile

USE WITH AWARENESS

Generally safeUse with awarenessProfessional use
IFRA approved with restrictions
Potential sensitizer at high concentrations
CAS
103-95-7
Formula
Mixture
MW
Variable
Odor Family
Layer 1 · Enthusiast

What Does Cyclamen Aldehyde Smell Like?

Cyclamen Aldehyde opens with a crisp, dewy greenness like crushed stems, evolving into a radiant floral heart reminiscent of lily-of-the-valley with a watery freshness. The dry-down reveals a soft powdery muskiness with subtle cucumber-like undertones. Its diffusive character creates an airy floral halo, making it invaluable for modern floral compositions where a clean, transparent floralcy is desired.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Diorissimo(Christian Dior, 1956)

Used as a modern lily-of-the-valley replacer, providing the signature dewy floralcy while improving stability and diffusion compared to natural extracts.

L’Interdit(Givenchy, 1957)

Forms the crisp green floral backbone, balancing tuberose’s creaminess with its refreshing cucumber-floral character.

Pleasures(Estée Lauder, 1995)

Provides the transparent floralcy that defines this modern floral, creating an airy freshness throughout the composition.

En Passant(Frédéric Malle, 2000)

Used for its watery lilac facet, contributing to the fragrance’s rain-drenched floral impression.

Chance Eau Tendre(Chanel, 2010)

Forms the crisp green-floral core that makes this fragrance simultaneously delicate and radiant.

Layer 2

2D Molecular Structure

Cyclamen aldehyde

SMILES: CC(CC1=CC=C(C=C1)C(C)C)C=O

Chemistry, Properties & Perfumer Guide

The Chemistry

Cyclamen Aldehyde (3-(4-isopropylphenyl)-2-methylpropanal) belongs to the aryl aldehyde class. While not found in nature, it mimics the scent of cyclamen and lily-of-the-valley flowers. Industrially produced via aldol condensation of cuminaldehyde with propionaldehyde, followed by hydrogenation. The commercial material typically contains about 30% of the active aldehyde due to stability considerations, often diluted in DEP or other solvents.

Physical & Chemical Properties

Boiling Point 270 °C (estimated)
Flash Point >100 °C
Appearance Colorless to pale yellow liquid

Perfumer Guide

Note Position
Heart
Volatility
Medium (2-6 hours)
Blending
Excellent
Application Typical % Range Notes
Fine Fragrance 1-3% Up to 5% Floral compositions, lily accords
Soap 0.5-1% Up to 2% Provides stable floralcy
Detergents 0.1-0.5% Up to 1% Fresh floral boost

Classic Accords

+ Hydroxycitronellal + Lilial = Muguet
+ Lyral + Hedione = Modern Floral
+ Phenyl Ethyl Alcohol = Rosy-Fresh

Tip: Combine with citrus top notes to enhance freshness, or musks to extend its powdery dry-down.

Alternatives & Comparisons

1
Lilial CAS 80-54-6

Stronger floralcy with less greenness, used when more pronounced lily character is desired.

2
Hydroxycitronellal CAS 107-75-5

Softer, more citrusy floral alternative for delicate compositions.

3
Lyral CAS 31906-04-4

More intense floralcy with better tenacity for long-lasting effects.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH, EU Cosmetics Regulation standards update periodically. Consult current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

IFRA 49th Amendment restricts to 11% in leave-on products (Category 1) due to sensitization potential.

EU Allergen Declaration

Not currently listed as an EU allergen.

GHS Classification

H315 Skin irritation
H319 Eye irritation

RIFM Assessment

RIFM assessment confirms safe use at current IFRA limits with proper risk management.

Sustainability

As a synthetic material, Cyclamen Aldehyde avoids natural resource depletion. Modern production methods aim to minimize solvent use and energy consumption. Being highly potent reduces the carbon footprint per kilogram of finished product.

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Industry & Science Data

Odor Detection Threshold
30 ppb
in air (orthonasal)
Ref: van Gemert, Odour Thresholds (2011)
Commercial Price
$30–$65/kg
synthetic grade, bulk market
Indicative 2024 pricing. Varies by purity & volume.
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References

  1. Bauer et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.
  2. IFRA Standards Library (2021). 49th Amendment. IFRA
  3. Arctander, S. (1969). Perfume and Flavor Chemicals.

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Mar 2026.

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Ingredient Data Sheet

CAS 103-95-7

Physical Properties

Molecular Weight190.28 g/mol🔬 PubChem
LogP (Octanol-Water)3.3🔬 PubChem
Boiling Point234 °C🔬 EPA CompTox
Vapor Pressure0.0023 mmHg @ 25°C📊 OPERA
Flash Point79.5 °C🔬 EPA CompTox
Involatility Index0.0002💻 Calculated
log Kp (skin permeability)-1.518💻 Calculated
SMILESCC(C)C1=CC=C(C=C1)CC(C)C=O🔬 PubChem

Volatility & Performance

Fragrance NoteBase💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score5.1 / 5💻 Calculated

Odor & Flavor

Functional Groupsaldehydearomatic💻 RDKit
“The commercial product is usually stabilized and adjusted to a suitable aldehyde strength, rarely higher than 95%, often about 70%. It is important that the stabilizer does not contribute to the odor of the aldehyde.”📖 Arctander
2-Methyl-3-(p-isopropylphenyl)-propionaldehyde has a strong, flowery odor.📖 Fenaroli

Flavor Notes (Arctander)

“Finds some use in flavor compositions, mainly for Citrus and various fruit flavor types. The concentration in the finished product is normally about 0.3 to 1.2 ppm (mere traces).”📖 Arctander

Sensory Thresholds

Odor Detection Threshold0 ppm📖 van Gemert

Regulatory Status

IFRA ListedYes — see IFRA Standards for category limits⚖️ IFRA 51
FEMA NumberFEMA 2743⚖️ FEMA GRAS
GRAS StatusGenerally Recognized as Safe⚖️ FEMA GRAS
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID2044769

Physical Properties

Molecular Weight 190.286 g/mol🔬 EPA CompTox
Density 0.949 g/cm^3🔬 EPA CTX
Boiling Point 234 °C🔬 EPA CTX
Melting Point 16.77 °C🔬 EPA CTX
Flash Point 79.5 °C🔬 EPA CTX
Refractive Index 1.497 Dimensionless📊 OPERA
Molar Volume 203.032 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 3.644 Log10 unitless📊 OPERA
LogD (pH 5.5) 3.644 Log10 unitless📊 OPERA
LogD (pH 7.4) 3.644 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 6.35 Log10 unitless📊 OPERA
Water Solubility 0 mol/L🔬 EPA CTX
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.002 mmHg🔬 EPA CTX
Viscosity 5.757 cP📊 OPERA
Surface Tension 32.926 dyn/cm📊 OPERA
Thermal Conductivity 131.754 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 17.07 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 1 count💻 Computed
Rotatable Bonds 4 count💻 Computed
Aromatic Rings 1 count💻 Computed
Molar Refractivity 59.398 cm^3/mol📊 OPERA
Polarizability 23.547 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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