Cyclohexyl cyclopent-2-ene-1-acetate (CAS 65405-69-8) — Woody Middle Note Fragrance Ingredient
Cyclohexyl cyclopent-2-ene-1-acetate
CAS 65405-69-8
What Is Cyclohexyl cyclopent-2-ene-1-acetate?
Cyclohexyl cyclopent-2-ene-1-acetate is a synthetic fragrance ingredient used in perfumes and scented products. It contributes to complex, modern fragrance compositions. This molecule matters because it helps create unique scent profiles that can’t be achieved with natural ingredients alone, offering perfumers more creative possibilities.
Safety Profile
GENERALLY SAFEWhat Does Cyclohexyl cyclopent-2-ene-1-acetate Smell Like?
Cyclohexyl cyclopent-2-ene-1-acetate offers a fresh, slightly woody aroma with subtle fruity undertones. The scent evolves from an initial crispness to a warmer, more rounded character over time. It blends aspects of green freshness with a smooth, almost ambery depth, making it versatile for modern fragrance constructions. The dry-down reveals a clean, slightly musky character that works well as a supporting note.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a bridge between citrus top notes and woody base notes, adding complexity without overpowering the composition.
Provides a green, slightly woody accent that enhances the fragrance’s contemporary interpretation of nature.
2D Molecular Structure
SMILES: O=C(CC1CCC=C1)OC1CCCCC1
Chemistry, Properties & Perfumer Guide
The Chemistry
Cyclohexyl cyclopent-2-ene-1-acetate belongs to the class of cyclic esters. While not found in nature, it is synthesized through esterification reactions between cyclohexanol and cyclopent-2-ene-1-acetic acid derivatives. The molecule features both cyclohexyl and cyclopentenyl moieties, creating a unique spatial configuration that influences its odor properties.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Used as a modifier and blender |
| Functional Fragrance | 0.5-1% | Up to 2% | Adds freshness to cleaning products |
Classic Accords
Tip: Use as a bridge between fresh top notes and woody base notes for better scent longevity.
Alternatives & Comparisons
For a simpler, more straightforward fruity-woody character when less complexity is desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA.
RIFM Assessment
No RIFM assessment currently available for this compound.
Sustainability
As a synthetic material, this ingredient doesn’t rely on agricultural resources. Its environmental impact depends on manufacturing processes and energy inputs during production.
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References
- Burdock, G.A. (2010). Fenaroli’s Handbook of Flavor Ingredients. CRC Press.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 65405-69-8Physical Properties
| Molecular Weight | 208.3 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 3.3🔬 PubChem |
| Boiling Point | 267 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0085 mmHg @ 25°C📊 OPERA |
| Flash Point | 118.9 °C🔬 EPA CompTox |
| Involatility Index | 0.0006💻 Calculated |
| log Kp (skin permeability) | -1.628💻 Calculated |
| SMILES | C1CCC(CC1)OC(=O)CC2CCC=C2🔬 PubChem |
Volatility & Performance
| Fragrance Note | Heart💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 4.1 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | greenwoody• leffingwell |
| Functional Groups | esteretheralkene💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID5052337
Physical Properties
| Molecular Weight | 208.301 g/mol🔬 EPA CompTox |
| Density | 1.023 g/cm^3📊 OPERA |
| Boiling Point | 270.702 °C📊 OPERA |
| Melting Point | 17.422 °C📊 OPERA |
| Flash Point | 128.518 °C📊 OPERA |
| Refractive Index | 1.5 Dimensionless📊 OPERA |
| Molar Volume | 203.62 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.829 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.829 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.829 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.88 Log10 unitless📊 OPERA |
| Water Solubility | 0.001 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.004 mmHg📊 OPERA |
| Viscosity | 6.271 cP📊 OPERA |
| Surface Tension | 35.242 dyn/cm📊 OPERA |
| Thermal Conductivity | 135.459 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 26.3 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 3 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 59.877 cm^3/mol📊 OPERA |
| Polarizability | 23.737 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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