Ethylenediaminetetraacetic acid disodium salt (CAS 6381-92-6) — Citrus N/A Note Fragrance Ingredient
Ethylenediaminetetraacetic acid disodium salt
CAS 6381-92-6
What Is Ethylenediaminetetraacetic acid disodium salt?
Ethylenediaminetetraacetic acid disodium salt (EDTA) is a synthetic compound commonly used in cosmetics and personal care products as a preservative and stabilizer. It helps maintain product integrity by binding metal ions that can cause spoilage or discoloration. EDTA is found in shampoos, conditioners, and skincare products where it enhances the effectiveness of other ingredients.
Safety Profile
GENERALLY SAFEWhat Does Ethylenediaminetetraacetic acid disodium salt Smell Like?
EDTA is odorless, making it a versatile ingredient in fragrance formulations where it serves as a stabilizer rather than a scent contributor. Its primary role is to chelate metal ions, preventing oxidation and maintaining the integrity of delicate fragrance notes over time.
Chemistry, Properties & Perfumer Guide
The Chemistry
EDTA is a synthetic chelating agent belonging to the class of polyaminocarboxylic acids. It is widely used in industrial and cosmetic applications due to its ability to bind metal ions. The disodium salt form enhances its solubility in water, making it suitable for aqueous formulations. EDTA is synthesized through the reaction of ethylenediamine with formaldehyde and sodium cyanide, followed by hydrolysis.
Physical & Chemical Properties
| Melting Point | 248 °C |
|---|---|
| Solubility | Soluble in water |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Cosmetics | 0.1-0.5% | Up to 1% | Used as a preservative and stabilizer |
Classic Accords
Tip: Use EDTA to enhance the stability of fragrance formulations by preventing metal ion-induced degradation.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not restricted by IFRA.
RIFM Assessment
RIFM has assessed EDTA as safe for use in fragrances at typical concentrations.
Sustainability
EDTA is synthetic and not biodegradable, raising environmental concerns. Alternatives like sodium citrate are being explored for more sustainable formulations.
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References
- PubChem. Ethylenediaminetetraacetic acid disodium salt. PubChem CID: 6381-92-6
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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