Formaldehyde cyclododecyl ethyl acetal (CAS 58567-11-6) — Woody Base Note Fragrance Ingredient
Formaldehyde cyclododecyl ethyl acetal
CAS 58567-11-6
What Is Formaldehyde cyclododecyl ethyl acetal?
Formaldehyde cyclododecyl ethyl acetal is a synthetic fragrance ingredient used in fine perfumery. It creates woody, ambery, and slightly animalic nuances in compositions. This material is found in niche fragrances where complex base notes are desired.
Safety Profile
USE WITH AWARENESSWhat Does Formaldehyde cyclododecyl ethyl acetal Smell Like?
Presents a complex interplay of woody-ambery depth with subtle animalic undertones. The initial impression is dry and slightly phenolic, evolving into a warm, musky base reminiscent of aged woods and leather. Acts as a powerful fixative, adding tenacity to fragrance compositions with a dry-down that lingers between smoky and sweet.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used for its challenging animalic facets, contributing to the controversial metallic-blood accord that defines this avant-garde composition.
Provides woody-amber backbone to the ink accord, creating a dry, persistent base note that contrasts with the floral top.
2D Molecular Structure
SMILES: CCOCOC1CCCCCCCCCCC1
Chemistry, Properties & Perfumer Guide
The Chemistry
Formaldehyde cyclododecyl ethyl acetal belongs to the class of cyclic acetals. These compounds are formed through the reaction of aldehydes with alcohols. The cyclododecyl structure provides excellent stability and longevity in fragrance applications. The molecule’s conformational flexibility allows it to interact with multiple olfactory receptors.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Used sparingly for woody-amber effects |
| Functional Fragrance | Not used | Not used | Generally avoided due to restrictions |
Classic Accords
Tip: Use in trace amounts to avoid overwhelming compositions – works best when balanced with clean musks.
Alternatives & Comparisons
Provides similar ambery effects without formaldehyde concerns. More widely accepted in modern perfumery.
Offers powerful woody notes with better safety profile. Creates similar diffusion effects.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Restricted under IFRA standards due to potential formaldehyde release. Not permitted in products intended to remain on skin.
GHS Classification
RIFM Assessment
Assessed by RIFM with usage restrictions recommended due to sensitization potential.
Sustainability
Synthetic production minimizes environmental impact compared to natural alternatives. Manufacturing process requires controlled conditions to prevent formaldehyde emissions. Not derived from animal sources.
Explore Formaldehyde cyclododecyl ethyl acetal
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References
- IFRA Standards Library (2023). Amendment 49 Restricted Materials List. IFRA Standards
- SCCS Opinion on Formaldehyde (2019). Scientific Committee on Consumer Safety. EU SCCS
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 58567-11-6Physical Properties
| Molecular Weight | 242.4 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 5.5🔬 PubChem |
| Boiling Point | 290.1 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0022 mmHg @ 25°C📊 OPERA |
| Flash Point | 136 °C🔬 EPA CompTox |
| Involatility Index | 0.0002💻 Calculated |
| log Kp (skin permeability) | -0.274💻 Calculated |
| SMILES | CCOCOC1CCCCCCCCCCC1🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 7 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | balsamicwoody• leffingwell |
| Functional Groups | ether💻 RDKit |
Regulatory Status
| IFRA Listed | Yes — see IFRA Standards for category limits⚖️ IFRA 51 |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID1052248
Physical Properties
| Molecular Weight | 242.403 g/mol🔬 EPA CompTox |
| Density | 0.934 g/cm^3🔬 EPA CTX |
| Boiling Point | 290.1 °C🔬 EPA CTX |
| Melting Point | 2.249 °C📊 OPERA |
| Flash Point | 136 °C🔬 EPA CTX |
| Refractive Index | 1.452 Dimensionless📊 OPERA |
| Molar Volume | 270.329 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.4 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 5.612 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.612 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.54 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.002 mmHg🔬 EPA CTX |
| Viscosity | 6.582 cP📊 OPERA |
| Surface Tension | 31.331 dyn/cm📊 OPERA |
| Thermal Conductivity | 144.175 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 18.46 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 4 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 72.918 cm^3/mol📊 OPERA |
| Polarizability | 28.907 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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