Menthone (CAS 10458-14-7) — Green Top-middle Note Fragrance Ingredient
Menthone
CAS 10458-14-7
What Is Menthone?
Menthone is a cooling, minty compound found naturally in peppermint and other mint oils. It’s commonly used in oral care products, chewing gum, and fragrances for its refreshing qualities. This ketone provides a crisp, clean character that enhances freshness in both flavor and fragrance applications.
Safety Profile
GENERALLY SAFEWhat Does Menthone Smell Like?
Menthone delivers an invigorating burst of crisp, cooling mint with a slightly herbal undertone. Imagine the sharp freshness of crushed peppermint leaves without the sweetness – more medicinal than candy-like. The scent evolves to reveal subtle woody nuances as it dries down, maintaining its clean character for hours.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Menthone provides the authentic mint leaf core in this modern fougère, creating cooling contrast against warm patchouli and earthy notes.
2D Molecular Structure
SMILES: CC(C)C1CCC(C)CC1=O
Chemistry, Properties & Perfumer Guide
The Chemistry
Menthone is a monoterpene ketone with two stereoisomers: (-)-menthone and (+)-isomenthone. Industrially produced via oxidation of menthol or from mint oil fractions. The ketone group contributes to its cooling sensation through TRPM8 receptor activation.
Physical & Chemical Properties
| Boiling Point | 207-210 °C |
|---|---|
| Density | 0.895 g/cm³ |
| Flash Point | 76 °C |
| Vapor Pressure | 0.15 mmHg at 25°C |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Oral Care | 0.1-0.5% | Up to 1% | Provides cooling sensation |
| Fine Fragrance | 0.5-2% | Up to 5% | Fresh top note modifier |
Classic Accords
Tip: Use with cooling agents like WS-23 to enhance the physiological cooling effect.
Alternatives & Comparisons
When longer-lasting cooling is needed without strong mint odor. Used in skincare for persistent cooling effect.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under current IFRA standards.
RIFM Assessment
RIFM assessment confirms safety at current usage levels in fragrances.
Sustainability
Most commercial menthone is synthesized from renewable turpentine feedstocks. Natural extraction from mint oil remains niche due to cost. Biocatalytic production methods are being developed for greener synthesis.
Explore Menthone
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References
- PubChem Compound Summary for Menthone CID 26447
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorLayer 3 · Practical
- Molecular Weight: 154.25 g/mol
- LogP (XLogP): 2.70
Physicochemical Properties
DTXSID: DTXSID80859154
Physical Properties
| Molecular Weight | 154.253 g/mol🔬 EPA CompTox |
| Density | 0.878 g/cm^3📊 OPERA |
| Boiling Point | 205.02 °C📊 OPERA |
| Melting Point | -6 °C🔬 EPA CTX |
| Flash Point | 72.22 °C📊 OPERA |
| Refractive Index | 1.443 Dimensionless📊 OPERA |
| Molar Volume | 175.053 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.102 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.102 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.102 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.85 Log10 unitless📊 OPERA |
| Water Solubility | 0.004 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.276 mmHg📊 OPERA |
| Viscosity | 2.597 cP📊 OPERA |
| Surface Tension | 28.094 dyn/cm📊 OPERA |
| Thermal Conductivity | 124.604 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 46.374 cm^3/mol📊 OPERA |
| Polarizability | 18.384 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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