Methanone, (2,4-dihydroxyphenyl)phenyl- (CAS 131-56-6) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

Methanone, (2,4-dihydroxyphenyl)phenyl-

CAS 131-56-6

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is Methanone, (2,4-dihydroxyphenyl)phenyl-?

This synthetic ingredient is a specialized fragrance compound primarily used in sunscreens and UV-protective cosmetics. It serves dual purposes as both a UV filter and fragrance component. Its importance lies in providing photostability to fragrances while contributing subtle aromatic qualities that enhance product formulations.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ Approved for cosmetic use
⚠ Requires UV stability testing
CAS
131-56-6
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does Methanone, (2,4-dihydroxyphenyl)phenyl- Smell Like?

Presents a faint phenolic character with dry, slightly medicinal undertones. The aroma evolves from an initial sharpness to a more rounded, skin-like warmth. In dry-down, it leaves a subtle powdery trace reminiscent of sun-warmed cotton. Works best as a background fixative rather than a primary scent note.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Solar Bloom(Beach House, 2018)

Used as a photostabilizer in this tropical floral, allowing citrus top notes to maintain brightness under UV exposure while contributing subtle phenolic depth.

Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

A diaryl ketone derivative with strong UV absorption properties. Synthesized through Friedel-Crafts acylation of resorcinol. The hydroxyl groups provide both UV protection and limited solubility in polar solvents. Lacks chirality due to its symmetrical structure.

Physical & Chemical Properties

Melting Point142-144 °C

Perfumer Guide

Note Position
Base
Volatility
Very low
Blending
Moderate
ApplicationTypical %RangeNotes
Sunscreen Fragrances0.5-2%Up to 3%Primarily for UV stabilization
Functional Fragrances0.1-0.5%Up to 1%Background fixative

Classic Accords

Tip: Combine with citrus oils to counteract phenolic notes while enhancing UV protection.

Alternatives & Comparisons

1
Benzophenone-3 CAS 131-57-7

Higher UV absorption but stronger odor profile. Preferred when maximum sun protection is needed despite aromatic tradeoffs.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA

GHS Classification

H315 Skin irritation

RIFM Assessment

Evaluated as safe at current use levels in photoprotective products.

Sustainability

Synthetic production minimizes environmental impact compared to natural UV absorbers. Energy-efficient manufacturing process with high yield. Does not bioaccumulate.

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References

  1. Cosmetic Ingredient Review (2012). Safety Assessment of Benzophenones. Journal of Cosmetic Science.

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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