Phenol, 2-(1,1-dimethylethyl)-6-methyl- (CAS 2219-82-1) — Woody Middle to base Note Fragrance Ingredient
Phenol, 2-(1,1-dimethylethyl)-6-methyl-
CAS 2219-82-1
What Is Phenol, 2-(1,1-dimethylethyl)-6-methyl-?
This synthetic fragrance ingredient is a modified phenol compound used in specialty perfumery. Consumers might encounter it in niche fragrances where its unique woody-phenolic character adds depth. The molecule matters because it bridges traditional phenolic notes with modern woody-amber accords, offering perfumers a versatile building block for contemporary compositions.
Safety Profile
USE WITH AWARENESSWhat Does Phenol, 2-(1,1-dimethylethyl)-6-methyl- Smell Like?
A complex phenolic-woody aroma with facets of smoked birch and antique furniture polish. Opens with sharp medicinal top notes that quickly resolve into a dry, slightly camphoraceous heart. The dry-down reveals surprising warmth – like sun-baked driftwood with whispers of leather and clove. Acts as both fixative and modifier, adding phenolic bite to woody bases while taming sweetness in oriental accords.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Showcases this phenol derivative as the sole note, demonstrating its surprising complexity – from initial phenolic sharpness to a smooth woody dry-down that lasts for hours.
Used as a birch tar alternative, contributing smoky depth without the traditional phenolic harshness in this Nordic-inspired woody composition.
Chemistry, Properties & Perfumer Guide
The Chemistry
A tert-butyl substituted phenol with methyl group ortho to the hydroxyl. The bulky tert-butyl group sterically hinders the phenolic OH, reducing reactivity while maintaining aromatic character. Synthesized via Friedel-Crafts alkylation of p-cresol with isobutylene. The methyl group’s position creates electron density shifts that modify the phenolic character, yielding a more balanced odor profile than simple phenols.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | ~230 °C (estimated) |
| Density | ~0.95 g/cm³ (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Adds phenolic complexity |
| Functional Fragrance | 0.1-0.5% | Up to 1% | Used sparingly for woody depth |
Classic Accords
Tip: Use in trace amounts to add phenolic edge without overwhelming – balances particularly well with ionones and woody ambers.
Alternatives & Comparisons
For a more traditional smoky phenolic character, though significantly harsher and less refined than the tert-butyl derivative.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards, but phenolic compounds require careful evaluation in formulations.
GHS Classification
RIFM Assessment
No specific RIFM assessment found – evaluate as phenolic compound.
Sustainability
As a synthetic material, production involves petrochemical feedstocks but avoids natural resource depletion. Modern synthesis routes aim for atom economy and reduced waste streams compared to traditional phenol chemistry.
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References
- Bauer et al. (2001). Modern Phenolic Chemistry in Perfumery. Flavour and Fragrance Journal. DOI:10.1002/ffj.1005
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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