Phenol, 2-methoxy-, reaction products (CAS 224790-80-1) — Woody Base Note Fragrance Ingredient
Phenol, 2-_methoxy-_, reaction products
CAS 224790-80-1
What Is Phenol, 2-_methoxy-_, reaction products?
This synthetic ingredient is a modified phenol compound used in industrial fragrance applications. Consumers might encounter it in household products or functional fragrances where cost-effective aroma chemicals are needed. While not common in fine perfumery, it serves as a building block for creating specific scent profiles in mass-market products.
Safety Profile
USE WITH AWARENESSWhat Does Phenol, 2-_methoxy-_, reaction products Smell Like?
This synthetic phenol derivative presents a sharp, medicinal character with phenolic undertones. The initial impression is intensely chemical with rubbery, smoky facets that gradually soften into a more subdued industrial aroma. It lacks the complexity of natural materials, settling into a flat, persistent base note that functions more as a fixative than a primary aroma.
Chemistry, Properties & Perfumer Guide
The Chemistry
This synthetic material belongs to the phenol ether class, created through methoxylation reactions of phenol derivatives. The reaction products mixture lacks precise chemical definition, typical of industrial fragrance intermediates. Production typically involves Friedel-Crafts alkylation or other electrophilic aromatic substitution methods under controlled conditions to achieve the desired substitution pattern.
Physical & Chemical Properties
| Appearance | Not specified |
|---|---|
| Molecular Class | Phenol ether derivatives |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Functional Fragrances | 0.1-1% | Up to 3% | Fixative and modifier |
| Household Products | 0.5-2% | Up to 5% | Cost-effective base |
Classic Accords
Tip: Use sparingly to avoid overwhelming phenolic character in blends.
Alternatives & Comparisons
A more defined phenol ether with similar smoky characteristics but better documented safety profile.
Offers related phenolic notes with greater floral nuance for fragrance applications.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not specifically restricted by IFRA, but falls under general phenol guidelines.
GHS Classification
RIFM Assessment
No specific RIFM evaluation available for this reaction products mixture.
Sustainability
As a synthetic material, production involves petrochemical feedstocks with associated environmental impacts. The undefined nature of the reaction products mixture makes full lifecycle assessment challenging. Industrial scale production typically prioritizes cost efficiency over green chemistry principles.
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References
- IFRA Standards Library IFRA Guidelines
- EU CosIng Database CosIng
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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