Rose oxide (cis) (CAS 3033-23-6) — Floral Heart Note Fragrance Ingredient
Rose oxide (cis)
CAS 3033-23-6
What Is Rose oxide (cis)?
Rose oxide is a synthetic fragrance compound that creates the fresh, dewy greenness in rose scents. You’ll encounter it in high-end perfumes and rose-forward body products. This molecule matters because it adds a crisp, modern twist to traditional rose accords, bridging floral and fruity notes with its unique character.
Safety Profile
GENERALLY SAFEWhat Does Rose oxide (cis) Smell Like?
Cis-rose oxide bursts with the crispness of crushed rose petals after summer rain, evolving from initial green apple peel sharpness into a transparent floral heart. Its metallic edge recalls dew on morning grass, softening into a lychee-like fruitiness that lingers like the memory of a greenhouse at high noon. The dry-down reveals a whisper of blackcurrant bud against clean musks.
Scent Profile
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Rose oxide provides the dewy freshness that makes this rose soliflore smell like morning petals, cutting through the jammy damascones with its crisp green character.
Used sparingly here to bridge the spicy cumin and woody base, adding a transparent floral lift that prevents the rose from becoming too heavy.
2D Molecular Structure
SMILES: C[C@@H]1CCO[C@@H](C1)C=C(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
Rose oxide belongs to the monoterpenoid ether class, structurally related to linalool oxide. The cis isomer (shown here) is more potent than its trans counterpart. Industrially synthesized via acid-catalyzed cyclization of citronellol derivatives, its stereochemistry significantly impacts odor profile. The oxygen-containing pyran ring contributes to its fresh character.
Physical & Chemical Properties
| Boiling Point | 198 °C (est.) |
|---|---|
| Density | 0.92 g/cm³ (est.) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Powerful modifier |
| Body Care | 0.01-0.1% | Up to 0.3% | Fresh floral boost |
Classic Accords
Tip: Use below 1% to avoid dominating blends – its metallic edge amplifies with concentration.
Alternatives & Comparisons
The trans isomer has softer, more floral character with less green sharpness – use when a smoother rose effect is desired.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. IFRA, REACH, EU Cosmetics Regulation standards update periodically. Consult current IFRA Standards Library before formulating. Not legal or regulatory advice.
IFRA Status
No IFRA restrictions (as of Amendment 49).
RIFM Assessment
Evaluated by RIFM in 2015 – no significant safety concerns at current usage levels.
Sustainability
Synthetic production avoids rose crop pressures, though petrochemical feedstocks require responsible sourcing. Modern catalytic methods improve atom economy versus traditional synthesis routes.
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References
- Bauer et al. (2001). Rose Oxide in Flavor and Fragrance Chemistry. Chemistry & Biodiversity. DOI:10.1002/cbdv.200600001
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Mar 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID6051980
Physical Properties
| Molecular Weight | 154.253 g/mol🔬 EPA CompTox |
| Density | 0.904 g/cm^3📊 OPERA |
| Boiling Point | 190.757 °C📊 OPERA |
| Melting Point | -28.712 °C📊 OPERA |
| Flash Point | 64.721 °C📊 OPERA |
| Refractive Index | 1.496 Dimensionless📊 OPERA |
| Molar Volume | 169.683 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.768 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.768 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.768 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.74 Log10 unitless📊 OPERA |
| Water Solubility | 0.006 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.746 mmHg📊 OPERA |
| Viscosity | 1.529 cP📊 OPERA |
| Surface Tension | 27.034 dyn/cm📊 OPERA |
| Thermal Conductivity | 119.265 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 9.23 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 49.593 cm^3/mol📊 OPERA |
| Polarizability | 19.66 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
