Terpenes and Terpenoids, patchouli-oil, a-guaiene fraction, oxidized (CAS 1442462-94-3) — Woody Base Note Fragrance Ingredient

Woody · Balsamic

Terpenes and Terpenoids, patchouli-oil, a-guaiene fraction, oxidized

CAS 1442462-94-3

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is Terpenes and Terpenoids, patchouli-oil, a-guaiene fraction, oxidized?

Oxidized α-guaiene is a refined fragrance material derived from patchouli oil. It’s found in woody, earthy perfumes and some luxury skincare products. This ingredient enhances depth and longevity in fragrances, contributing a sophisticated aged-patchouli character that’s smoother than raw patchouli oil.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
IFRA compliant in standard applications
Potential sensitizer at high concentrations
CAS
1442462-94-3
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does Terpenes and Terpenoids, patchouli-oil, a-guaiene fraction, oxidized Smell Like?

Oxidized α-guaiene unfolds with an initial damp forest floor earthiness that gradually reveals aged leather and tobacco nuances. The dry-down carries a warm, ambery woodiness with subtle animalic undertones reminiscent of fine antique wood cabinets. Unlike raw patchouli, it lacks the sharp camphoraceous edge, instead offering a rounded, almost honeyed decay that blends seamlessly with oriental and chypre bases.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Patchouli Absolu(Guerlain, 2019)

Used here to create a polished, contemporary patchouli interpretation that avoids the hippie associations of raw patchouli, adding velvety depth without overwhelming sweetness.

Coromandel(Chanel, 2016)

The oxidized guaiene fraction contributes to the fragrance’s signature ‘white patchouli’ effect, softening the earthiness with a clean, almost powdery wood character.

Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

Oxidized α-guaiene is a sesquiterpene derivative formed through controlled oxidation of patchouli oil’s natural α-guaiene content. The oxidation process creates oxygenated derivatives including guaiene epoxides and alcohols, which modify the scent profile. Industrial production typically involves photo-oxidation or metal-catalyzed oxidation of isolated guaiene fractions.

Physical & Chemical Properties

AppearanceViscous pale amber liquid
SolubilitySoluble in alcohol and oils

Perfumer Guide

Note Position
Base
Volatility
Very low (24+ hours)
Blending
Excellent with woods, ambers, and musks
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Base note modifier
Home Fragrance1-3%Up to 8%Adds warmth to woody diffuser blends

Classic Accords

Tip: Use to ‘age’ new compositions instantly – adds the character of well-matured perfumes without actual aging time.

Alternatives & Comparisons

1
Patchouli Heart Fraction CAS 8014-09-3

For a cleaner patchouli effect without oxidation notes. Retains more of the original camphoraceous character.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific restrictions under IFRA 51st Amendment. Subject to general patchouli oil guidelines.

EU Allergen Declaration

Not listed as EU allergen, but may contain trace oxidation byproducts requiring declaration.

GHS Classification

H317 May cause allergic skin reaction

RIFM Assessment

RIFM assessment pending for oxidized guaiene fractions. Currently evaluated under patchouli oil safety data.

Sustainability

Synthetic production reduces pressure on natural patchouli crops while allowing precise control of oxidation byproducts. The process minimizes waste by utilizing byproducts from patchouli oil fractionation.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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    Ingredient Data Sheet

    CAS 1442462-94-3
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

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