Tetrahydromyrcenol (CAS 18479-57-7) — Citrus Top to middle Note Fragrance Ingredient
Tetrahydromyrcenol
CAS 18479-57-7
What Is Tetrahydromyrcenol?
Tetrahydromyrcenol is a synthetic fragrance ingredient commonly found in modern perfumes and body care products. It provides a fresh, citrusy-woody scent that enhances shower gels, deodorants, and light colognes. This versatile molecule matters because it bridges citrus freshness with subtle woody depth, creating gender-neutral appeal in functional fragrances where lasting power is needed without heaviness.
Safety Profile
GENERALLY SAFEWhat Does Tetrahydromyrcenol Smell Like?
Tetrahydromyrcenol opens with a crisp, almost metallic citrus burst reminiscent of freshly peeled grapefruit rind. As it evolves, the sharpness softens into a rounded woody character – imagine young sapling sap meeting polished cedar panels. The dry-down reveals a clean muskiness akin to sun-warmed skin after swimming in a pine-fringed lake. Unlike traditional citrus notes, it maintains remarkable tenacity on skin while avoiding any soapy or harsh tonalities.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a synthetic alternative to traditional citrus top notes, providing longer-lasting freshness that blends seamlessly with the aquatic and woody accords.
Employed for its ability to bridge citrus and woody elements, creating the fragrance’s signature water-tinged freshness with unusual persistence.
2D Molecular Structure
SMILES: CCC(C)CCCC(C)(C)O
Chemistry, Properties & Perfumer Guide
The Chemistry
Tetrahydromyrcenol is a monoterpenoid alcohol synthesized from myrcene. The hydrogenation process creates a more stable molecule compared to its natural terpene counterparts. While not found in nature, it structurally resembles components of petitgrain and hops. The saturated form eliminates photoinstability issues common to citrus terpenes while maintaining desirable olfactory properties.
Physical & Chemical Properties
| Boiling Point | 198 °C |
|---|---|
| Density | 0.865 g/cm³ |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 5-15% | Up to 20% | Fresh woody-citrus core |
| Functional Products | 1-5% | Up to 10% | Long-lasting freshness |
Classic Accords
Tip: Use to extend citrus top notes while adding subtle woody complexity without darkening the fragrance profile.
Alternatives & Comparisons
The unsaturated precursor, offering brighter citrus character but with less stability and higher volatility.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No current IFRA restrictions. Compliant under all categories.
RIFM Assessment
RIFM assessment confirms safe use at current industry levels.
Sustainability
As a synthetic material, Tetrahydromyrcenol reduces pressure on natural citrus oil production. Modern synthesis routes achieve high atom efficiency with minimal hazardous byproducts. The long-lasting character means lower quantities are needed compared to natural citrus oils.
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References
- Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH. ISBN 978-3-527-30656-9
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorPhysicochemical Properties
DTXSID: DTXSID0044810
Physical Properties
| Molecular Weight | 158.285 g/mol🔬 EPA CompTox |
| Density | 0.827 g/cm^3🔬 EPA CTX |
| Boiling Point | 201.9 °C🔬 EPA CTX |
| Melting Point | -26.011 °C📊 OPERA |
| Flash Point | 72 °C🔬 EPA CTX |
| Refractive Index | 1.434 Dimensionless📊 OPERA |
| Molar Volume | 191.534 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.2 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 3.456 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.456 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 6.42 Log10 unitless📊 OPERA |
| Water Solubility | 0.002 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.07 mmHg🔬 EPA CTX |
| Viscosity | 5.199 cP📊 OPERA |
| Surface Tension | 26.372 dyn/cm📊 OPERA |
| Thermal Conductivity | 137.127 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 20.23 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 5 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 49.837 cm^3/mol📊 OPERA |
| Polarizability | 19.757 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
