(+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate (CAS 252736-41-7) — Mid Note Fragrance Ingredient

ByThe Good Scents



gourmand

(+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate

CAS 252736-41-7

Note
mid
Volatility
medium
MW
160.2
Data as of: Jun 2026

What Is (+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate?

(+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate (CAS 252736-41-7) is an aroma chemical used as a fragrance and flavour ingredient. Its odour is described as green, rose and sour, placing it within the gourmand family as a mid note with medium volatility. With a molecular weight of 160.2 (formula C7H12O2S), it is handled by perfumers as a building block for compositions where a green character is desired. The data below is compiled from public chemical and regulatory sources.

Safety Profile

USE WITH AWARENESS

Generally safeUse with awarenessProfessional use
CAS
252736-41-7
Formula
C7H12O2S
MW
160.2
InChIKey
HZJHVQDTGJRROR-UHFFFAOYNA-N
(+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate 2D structure

(+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate
C7H12O2S
Layer 1 · Enthusiast

What Does (+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate Smell Like?

The odour profile of (+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate is reported as green, rose, sour, sweet. The dominant facet is its green character, with the remaining notes adding nuance and complexity. As a mid note it contributes to the heart of a fragrance. Perceived intensity and exact character depend on concentration, the carrier and the surrounding accord.

Scent Profile

Profile derived from public odour-descriptor data; relative, not absolute.

Layer 2

Chemistry & Properties

The Chemistry

(+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate has the molecular formula C7H12O2S and a molecular weight of 160.2 g/mol. Its canonical SMILES representation is CC1OCCC1SC(C)=O. Its reported log P (XLogP) of 1.44 indicates a moderately polar molecule, which informs how it partitions in a formula. Physical constants below are drawn from PubChem and EPA CompTox public datasets.

Physical & Chemical Properties

Molecular Weight 160.2 g/mol
Boiling Point 221.5 °C
Melting Point 28.65 °C
Flash Point 80.11 °C
Density 0.9432 g/cm³
Vapor Pressure 0.05178 mmHg
Water Solubility 0.06366 g/L
XLogP 1.44

Perfumer Guide

Note Position
Mid
Volatility
Medium
Primary Odour
Green

Alternatives & Comparisons

Ingredients occupying a similar odour space — useful as substitutes or companions when (+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate is unavailable or restricted.

1
7-(3,7-dimethylocta-2,6-dienoxy)-4-methylchromen-2-one CAS 50542-90-0

Shares floral, fruity, green character — a candidate substitute or companion in the same odour space.

2
para-Tolyl alcohol CAS 589-18-4

Shares balsamic, green, leafy character — a candidate substitute or companion in the same odour space.

3
2,5-Dimethyl-3-Thioisovalerylfuran CAS 55764-28-8

Shares green, tropical, sweet character — a candidate substitute or companion in the same odour space.

Layer 3

Safety & Regulatory

⚠ Regulatory Disclaimer

General reference only. IFRA, REACH and EU Cosmetics Regulation standards update periodically. Consult the current IFRA Standards Library before formulating. Not legal or regulatory advice.

IFRA Status

No IFRA restriction recorded in the data set. This is not a guarantee of unrestricted status — always confirm against the current IFRA Standards Library.

GHS Classification

Signal word: Warning

H302H315H319H335

Odour detection threshold (air): 6e-05 ppb — a literature-curated value indicating its potency in the vapour phase.

Formulating with (+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate?

Open (+/-)-2-Methyltetrahydrofuran-3-Thiol Acetate in Fragrance Studio (Pro) for the calibrated vapour-pressure curve, the modelled odour-threshold estimate, and the substitute-matching engine across 2,900+ aromachemicals.

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References & Sources

  1. PubChem Compound Summary (NIH) — search by InChIKey
  2. EPA CompTox Chemicals Dashboard — physicochemical & fate data
  3. IFRA Standards Library (49th / 51st Amendment)
Sources: PubChem (NIH) · EPA CompTox · IFRA Standards Library · public GHS classification. Odour descriptors are original editorial summaries of public profiles, not reproduced from any single proprietary source.

Data: PubChem (NIH), EPA CompTox, IFRA. Last reviewed: Jun 2026.

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