3-Methyldodecanonitrile (CAS 85351-07-01) — Woody Base Note Fragrance Ingredient

ByThe Good Scents
Woody · Musky

3-Methyldodecanonitrile

CAS 85351-07-01

Origin
synthetic
Note
Base
IFRA
Generally safe
Data as of: Apr 2026

What Is 3-Methyldodecanonitrile?

3-Methyldodecanonitrile is a synthetic fragrance ingredient primarily used in modern perfumery. It’s found in various personal care products where a clean, slightly musky scent is desired. This nitrile compound matters because it provides perfumers with a stable, long-lasting base note that can enhance the dry-down phase of fragrances without being overpowering.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe when used as directed
⚠ Limited safety data available
CAS
85351-07-01
Formula
Mixture
MW
Variable
Odor Family
Woody · Musky
Layer 1 · Enthusiast

What Does 3-Methyldodecanonitrile Smell Like?

3-Methyldodecanonitrile offers a subtle yet complex olfactory profile. It opens with a clean, slightly metallic edge reminiscent of freshly laundered linen, evolving into a soft muskiness akin to warm skin. The dry-down reveals a delicate woody-amber character with faint floral undertones, providing excellent tenacity without dominating a fragrance composition.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Molecule 04(Escentric Molecules, 2018)

Used as the sole active ingredient to showcase its unique musk-woody character, demonstrating how single molecules can create compelling fragrances.

Not a Perfume Superdose(Juliette Has a Gun, 2020)

Amplifies the skin-like musk effect when combined with other ambroxan-based accords, creating a personalized scent experience.

Layer 2

Chemistry, Properties & Perfumer Guide

The Chemistry

3-Methyldodecanonitrile belongs to the nitrile class of organic compounds, characterized by a carbon-nitrogen triple bond. While not found in nature, it’s synthesized through hydrocyanation of corresponding alkenes or via oxidation of primary amines. The branched methyl group at the 3-position affects its volatility and odor characteristics compared to linear nitriles.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Base
Volatility
Low (6+ hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Used as musk modifier
Body Care0.1-0.5%Up to 1%Provides subtle longevity

Classic Accords

Tip: Use at low concentrations to add diffusion and warmth without becoming cloying.

Alternatives & Comparisons

1
Helvetolide CAS 141773-73-1

Offers similar musk effects with better environmental degradation profile when sustainability is a priority.

2
Musk Ketone CAS 81-14-1

Traditional nitromusk alternative when regulatory restrictions allow, providing more pronounced animalic character.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

Under evaluation by RIFM with preliminary data showing favorable safety profile at current usage levels.

Sustainability

As a synthetic molecule, 3-Methyldodecanonitrile doesn’t require agricultural resources but does depend on petrochemical feedstocks. Its environmental impact is mitigated by high potency requiring minimal quantities in formulations. Biodegradability studies are ongoing.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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