4′-Hydroxy-3′-methoxyacetophenone (CAS 0498-02-02) — Woody Middle Note Fragrance Ingredient
4'-Hydroxy-3'-methoxyacetophenone
CAS 0498-02-02
What Is 4'-Hydroxy-3'-methoxyacetophenone?
4′-Hydroxy-3′-methoxyacetophenone is a synthetic fragrance ingredient used in perfumery. It’s not commonly encountered in everyday products but appears in niche fragrances. This molecule contributes to complex scent profiles, often adding depth to woody or spicy compositions.
Safety Profile
USE WITH AWARENESSWhat Does 4'-Hydroxy-3'-methoxyacetophenone Smell Like?
This synthetic molecule presents a warm, slightly phenolic character with subtle vanilla undertones. The initial impression is medicinal-aromatic, evolving into a dry woody-spicy heart. In drydown, it reveals faint smoky facets reminiscent of guaiacol derivatives. The overall profile is moderately tenacious with a clean, modern edge that works well in contemporary woody compositions.
Chemistry, Properties & Perfumer Guide
The Chemistry
4′-Hydroxy-3′-methoxyacetophenone belongs to the acetophenone class, specifically a methoxy-substituted derivative. It’s synthesized through Friedel-Crafts acylation of guaiacol derivatives. The molecule features a phenolic hydroxyl group and methoxy substitution pattern that influences its polarity and odor characteristics. While not chiral itself, its synthesis may involve chiral intermediates in some routes.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Melting Point | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-2% | Up to 5% | Used as woody-spicy modifier |
| Functional Fragrance | 0.1-1% | Up to 3% | For masculine accords |
Classic Accords
Tip: Use in trace amounts to add phenolic complexity without overwhelming the composition.
Alternatives & Comparisons
Similar structure with slightly softer profile, better solubility in alcohol bases.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply to this material.
RIFM Assessment
Limited safety assessment available. Considered safe at current usage levels.
Sustainability
As a synthetic material, this compound is produced through controlled chemical processes with minimal environmental impact. Being petroleum-derived, its sustainability depends on the manufacturer’s energy sources and waste management practices. No known ecological concerns at typical usage levels.
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